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Chromosome 21 workshop

1999; Wiley; Volume: 88; Issue: 3 Linguagem: Inglês

10.1002/(sici)1096-8628(19990618)88

1096-8628

David Curtis, Vincent M. Aita, Maayan Baron, Philip C. Bennett, S D Detera-Wadleigh, Andrew McQuillin, Daniela S. Gerhard, John R. Kelsoe, Tatiana Foroud,

Genetics and Neurodevelopmental Disorders

American Journal of Medical GeneticsVolume 88, Issue 3 p. 272-275 Chromosome 21 workshop D. Curtis, Corresponding Author D. Curtis Chair [email protected] Department of Psychological Medicine, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Royal London Hospital, London, U.K.Department of Psychological Medicine, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Royal London Hospital, London E1 1BB U.K.Search for more papers by this authorV.M. Aita, V.M. Aita Participant Columbia UniversitySearch for more papers by this authorM. Baron, M. Baron Participant Columbia UniversitySearch for more papers by this authorP. Bennett, P. Bennett Participant University of BirminghamSearch for more papers by this authorS. Detera-Wadleigh, S. Detera-Wadleigh Participant National Institute of Mental HealthSearch for more papers by this authorA. McQuillin, A. McQuillin Participant Royal Free and University College London Medical SchoolSearch for more papers by this authorD.S. Gerhard, D.S. Gerhard Contributor Washington University School of MedicineSearch for more papers by this authorJ.R. Kelsoe, J.R. Kelsoe Contributor University of California, San DiegoSearch for more papers by this authorT. Foroud, T. Foroud Contributor Indiana University School of MedicineSearch for more papers by this author D. Curtis, Corresponding Author D. Curtis Chair [email protected] Department of Psychological Medicine, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Royal London Hospital, London, U.K.Department of Psychological Medicine, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Royal London Hospital, London E1 1BB U.K.Search for more papers by this authorV.M. Aita, V.M. Aita Participant Columbia UniversitySearch for more papers by this authorM. Baron, M. Baron Participant Columbia UniversitySearch for more papers by this authorP. Bennett, P. Bennett Participant University of BirminghamSearch for more papers by this authorS. Detera-Wadleigh, S. Detera-Wadleigh Participant National Institute of Mental HealthSearch for more papers by this authorA. McQuillin, A. McQuillin Participant Royal Free and University College London Medical SchoolSearch for more papers by this authorD.S. Gerhard, D.S. Gerhard Contributor Washington University School of MedicineSearch for more papers by this authorJ.R. Kelsoe, J.R. Kelsoe Contributor University of California, San DiegoSearch for more papers by this authorT. Foroud, T. Foroud Contributor Indiana University School of MedicineSearch for more papers by this author First published: 25 October 2002 https://doi.org/10.1002/(SICI)1096-8628(19990618)88:3 3.0.CO;2-1Citations: 19AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract The report of the 1997 workshop presented overall evidence providing strong support for a susceptibility locus for bipolar disorder at C21q22-23. The 1998 workshop considered the latest results from four groups, and additional studies also have been incorporated into this report. The workshop noted that there was possibly a degree of overlap between the regions implicated by the large samples of the multiplex National Institute of Mental Health pedigrees (affected sib pair analysis: p = 0.0006) and the US/Israeli pedigrees of the New York group (admixture lod = 3.35), in an area a few centimorgans proximal to PFKL. Participants concluded that the evidence implicating this region remains as strong as any, and were optimistic that further investigation would eventually lead to the identification of a susceptibility gene. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:272–275, 1999. © 1999 Wiley-Liss, Inc. REFERENCES Aita VM, Liu J, Terwilliger JD, Baltazar R, Grunn A, Loth JE, Alexander JR, Lerer B, Endicott J, Wang Z, Penchaszdeh G, Knowles JA, Gilliam TC, Baron M. 1998. A follow-up linkage analysis of chromosome 21 continues to provide evidence for a putative bipolar affective disorder locus. Am J Med Genet 81: 477. Bennett P, Mulcahy T, Owen MJ, Craddock N, Gill M. 1998. The Wellcome Trust UK-Irish bipolar sib-pair study: chromosome 21. Am J Med Genet 81: 541. Byerley W, Holik J, Hoff M, Coon H. 1995. Search for a gene predisposing to manic depression on chromosome 21. Am J Med Genet 60: 231– 233. Collins A, Frezal J, Teague J, Morton NE. 1996. A metric map of humans: 23,500 loci in 850 bands. Proc Natl Acad Sci USA 93: 14771– 14775. Detera-Wadleigh, SD, Yoshikawa, T, Padigaru, M, Berrettini, WH, Badner, JA, Sanders, A, Goldin, LR, Turner, G, Rollins, DY, Moses, T, Esterling, L, Gershon, ES. 1998. Genome screen and candidate gene analysis in bipolar disorder. Am J Med Genet 81: 463. Ewald H, Eiberg M, Mors O, Flint T, Kruse TA. 1996. Linkage study between manic-depressive illness and chromosome 21. Am J Med Genet 67: 218– 224. Foroud T, Castellucio PF, Koller DL, Edenberg HJ, Goate A, Detera-Wadleigh, S, Stine, OC, McMahon, FJ, McInnis, MG, Rice, J, Blehar, M, Goldin, LR, Badner, J, Guroff, J, Reich, T, DePaulo, JR, Gershon, E, Nurnberger, JL. 1998. Genomewide scan of affected relative pairs using the NIMH genetics initiative bipolar affective disorder pedigrees. Am J Med Genet 81: 462. Gerhard DS, LaBuda MC, Nguyen LT, Armstrong C, Todd RD, Reich T. 1998. Results of a genome screen for genes predisposing to major affective disorder in two large kindreds. Am J Med Genet 81: 462. Gurling H. 1998. Chromosome 21 workshop. Psychiat Genet 8: 109– 113. Kelsoe JR, Loetscher E, Spence MA, Foguet M, Sadovnick AD, Remick RA, Flodman P, Masser D, Ungerleider S, Rapaport MH, Wishart WL, Luebert H. 1998. A genome survey of bipolar disorder indicates a susceptibility locus on chromosome 22. Am J Med Genet 81: 461. Kwok JBJ, Adams LJ, Salmon JA, Donald JA, Mitchell PB, Schofield PR. 1999. Nonparametric simulation based statistical analysis for bipolar disorder on chromosome 21q22.3. Am J Med Genet 88: 99– 102. LaBuda MC, Maldonado M, Marshall D, Otten K, Gerhard DS. 1996. A follow-up report of a genome search for affective disorder predisposition loci in the Old Order Amish. Am J Hum Genet 59: 1343– 1362. Liu J, Aita VM, Wang Z, Knowles JA, Terwilliger J, Matis TC, Grunn A, Ranta S, Endicott J, Loth JE, Lere B, Alexander JR, Ott J, Gilliam TC, Baron M. 1997. Progress in a genome wide search for genetic factors for bipolar disorder. Am J Med Genet 74: 590. McInnes LA, Escamilla MA, Service SK, Reus VI, Leon P, Silva S, Rojas E, Spesny M, Baharloo S, Blankenship K, Peterson A, Tyler D, Shimayoshi N, Tobey C, Batki S, Vinogradov S, Meza L, Gallegos A, Fournier E, Smith LB, Barondes SH, Sandkuijl LA, Freimer NB. 1996. A complete genome screen for genes predisposing to severe bipolar disorder in 2 Costa Rican pedigrees. Proc Nat Acad Sci USA 93: 13060– 13065. McQuillin A, Lawrence J, Curtis D, Kalsi G, Smyth C, Gurling HMD. 1998. An allelic association study of candidate genes in the chromosome 21q22.3 region implicated in bipolar affective disorder. Am J Med Genet 81: 544. Philibert RA, St. Jean, PL, Schork, NJ, Anderson, MC, Dalwadi, H, Damschroder-Williams, PJ, Doherty, AE, Dymarskaia, I, Ehlert, MA, Galdzicka, M, Lau, E, Long, RT, Patel, A, Paul, SP, Remortel, BG, Stubblefield, BK, Martin, BM, Allen, CR, Pauls, DI, Elston, RC, Egeland, JA, Paul, SM, Ginns, EI. 1997. A genome wide search for chromosome regions linked to bipolar affective disorder in the Old Order Amish identifies several candidate loci. Am J Med Genet 74: 585– 586. Raeymakers P, Verheyen GR, Van Zand, K, Souery, D, Claes, S, Godderis, J, Cassiman, JJ, Mendlewicz, J, Van Broeckhoven, C. 1997. Linkage studies with candidate regions in bipolar families. Am J Med Genet 74: 587. Shink E, Morisette J, Rochette D, Bordeleau L, Plante M, Villeneuve A, Barden N. 1998. Bipolar affective disorder susceptibility loci on chromosomes 5 and 21: heterogeneity in a homogeneous population in Quebec. Am J Med Genet 81: 541. Smyth CS, Kalsi G, Curtis D, Brynjolfsson J, O'Neill, J, Rifkin, L, Moloney, E, Murphy, P, Petursson, H, Gurling, HMD. 1997. Two locus admixture linkage analysis of bipolar and unipolar disorder supports the presence of susceptibility loci on chromosomes 11p15 and 21q22. Genomics 39: 1– 8. Straub RE, Lehner T, Luo Y, Loth JE, Shao W, Sharpe L, Alexander JR, Das K, Simon R, Fieve RR, Lerer B, Endicott J, Ott J, Gilliam TC, Baron M. 1994. A possible vulnerability locus for bipolar affective disorder on chromosome 21q22.3. Nat Genet 8: 291– 296. Vallada H, Craddock N, Vasques L, Curtis D, Kirov G, Lauriano V, Gentil V, Passos-Bueno, R, Murray, RM, Zatz, M, McGuffin, P, Powell, JF, Gill, M, Owen, M, Collier, DA. 1996. Linkage studies in bipolar affective disorder with markers on chromosome 21. J Affective Dis 41: 217– 221. Citing Literature Volume88, Issue318 June 1999Pages 272-275 ReferencesRelatedInformation