Produção Nacional
Revisado por pares
Hydrogel Based on Nanoclay and Gelatin Methacrylate Polymeric Matrix as a Potential Osteogenic Application
2023; Multidisciplinary Digital Publishing Institute; Volume: 14; Issue: 2 Linguagem: Inglês
10.3390/jfb14020074
ISSN2079-4983
AutoresDanielle Benigno de Andrade, Leticya L. S. Soares, Francisca L. A. Cardoso, Idglan S. de Lima, Jhaemely Gabrielly Vieira da Silva, Maria Acelina Martins de Carvalho, Maria G. Fonseca, Guilherme de Castro Brito, Francisco Eroni Paz dos Santos, Josy A. Osajima, Anderson Oliveira Lobo, Edson C. Silva-Filho,
Tópico(s)Facial Trauma and Fracture Management
ResumoA nanocomposite hydrogel has potentially applicability in the induction of osteogenesis. The hydrogel was synthesized using 1% gelatin methacrylate (GelMA), a biodegradable and bioactive polymer containing the structure of gelatin, denatured collagen derived from the extracellular bone matrix, and 6% laponite (Lap), a synthetic phyllosilicate of nanosized particles. Initially, 0.6 g of Lap was added to deionized water, and then a solution of GelMA/Igarcure was added under stirring and UV light for crosslinking. The spectra in the Fourier-transform infrared region showed bands that indicate the interaction between gelatin and methacrylate anhydride. X-ray diffraction patterns confirmed the presence of Lap and GelMA in the hydrogel. The thermogravimetric analysis suggested an increase in the thermal stability of the hydrogel with the presence of clay mineral. Rheological analysis showed that the hydrogel had a viscosity that allowed its injectability. The hydrogel did not show acute toxicity at any of the concentrations tested according to the
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