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Common neural correlates of vestibular stimulation and fear learning: an fMRI meta-analysis

2023; Springer Science+Business Media; Volume: 270; Issue: 4 Linguagem: Inglês

10.1007/s00415-023-11568-7

1432-1459

Nicola Neumann, Miquel À. Fullana, Joaquim Raduà, Thomas Brandt, Marianne Dieterich, Martín Lotze,

Action Observation and Synchronization

Abstract Background A bidirectional functional link between vestibular and fear-related disorders has been previously suggested. Objective To test a potential overlap of vestibular and fear systems with regard to their brain imaging representation maps. Methods By use of voxel-based mapping permutation of subject images, we conducted a meta-analysis of earlier functional magnetic resonance imaging (fMRI) studies applying vestibular stimulation and fear conditioning in healthy volunteers. Results Common clusters of concordance of vestibular stimulation and fear conditioning were found in the bilateral anterior insula cortex, ventrolateral prefrontal cortex and the right temporal pole, bilaterally in the adjacent ventrolateral prefrontal cortex, cingulate gyrus, secondary somatosensory cortex, superior temporal and intraparietal lobe, supplementary motor area and premotor cortex, as well as subcortical areas, such as the bilateral thalamus, mesencephalic brainstem including the collicular complex, pons, cerebellar vermis and bilateral cerebellar hemispheres. Peak areas of high concordance for activations during vestibular stimulation but deactivations during fear conditioning were centered on the posterior insula and S2. Conclusions The structural overlap of both networks allows the following functional interpretations: first, the amygdala, superior colliculi, and antero-medial thalamus might represent a release of preprogramed sensorimotor patterns of approach or avoidance. Second, the activation (vestibular system) and deactivation (fear system) of the bilateral posterior insula is compatible with the view that downregulation of the fear network by acute vestibular disorders or unfamiliar vestibular stimulation makes unpleasant perceived body accelerations less distressing. This also fits the clinical observation that patients with bilateral vestibular loss suffer from less vertigo-related anxiety.