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Pd(II)-catalyzed carboxylation of aromatic C─H bonds with CO 2

2023; American Association for the Advancement of Science; Volume: 9; Issue: 5 Linguagem: Inglês

10.1126/sciadv.adf2966

2375-2548

Gregor Kemper, Markus Hölscher, Walter Leitner,

Catalytic C–H Functionalization Methods

The carboxylation of nonactivated C─H bonds provides an attractive yet hitherto largely elusive chemical process to synthesize carboxylic acids by incorporation of CO2 into the chemical value chain. Here, we report on the realization of such a reaction using simple and nonactivated arenes as starting materials. A computationally designed Pd(II) complex acts as organometallic single-component catalyst, and apart from a base, necessary for thermodynamic stabilization of the intermediates, no other additives or coreagents are required. Turnover numbers up to 102 and high regioselectivities are achieved. The potential of this catalytic reaction for "green chemistry" is demonstrated by the synthesis of veratric acid, an intermediate for pharmaceutical production, from CO2 and veratrol.