Issue Information
2023; Wiley; Volume: 28; Issue: 2 Linguagem: Inglês
10.1111/gtc.12959
ISSN1365-2443
Tópico(s)RNA modifications and cancer
ResumoFront cover: Urashima Taro, the protagonist of a Japanese fairy tale, returned from his undersea utopia with his youth intact after hundreds of years, but as soon as he was exposed to the smoke from the souvenir Tamatebako (jeweled box), he turned into an old man. This painting depicts how the smoke causes Urashima Taro to lose not only his youth but also the Y chromosome in a part of his cells. Mosaic loss of chromosome Y (mLOY) is commonly observed in older men and has been linked to ageing and cancer, and has also been found to increase the risk of heart disease (Sano et al . (2022) Science 377: 292–297, DOI: 10.1126/science.abn3100). We referred to Fukami & Miyado (2022) Reprod. Med. Biol . 21: e12445, DOI: 10.1002/rmb2.12445 for the depiction of chromosomes. Designed by TRAIS Co., Ltd. (Kobe, Japan). image
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