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Effect of Induced Pulmonary Arterial Hypertension on Testicular Parameters of Wistar Rats Subjected to Resistance Exercise Training

2023; Oxford University Press; Volume: 29; Issue: 2 Linguagem: Inglês

10.1093/micmic/ozac037

1435-8115

Luiz Otávio Guimarães Ervilha, Leôncio Lopes Soares, Isabela da Silva Pereira Bento, Renner Philipe Rodrigues Carvalho, Thainá Iasbik Lima, Fernanda Carolina Ribeiro Dias, Daniel Silva Sena Bastos, Jamile Fernanda Silva Cossolin, Ana Cláudia Ferreira Souza, Emily Correna Carlo Reis, José Éduardo Serrão, Antônio José Natali, Mariana Machado‐Neves,

Endometriosis Research and Treatment

Abstract Pulmonary arterial hypertension (PAH) is characterized by elevated arterial pressure and vascular resistance. PAH may cause alterations in the microcirculation of several organs, including the kidney, liver, brain, and testes. However, it remains unclear whether monocrotaline-induced PAH exerts detrimental effects on animal testes. Thus, we analyzed the impact of PAH on testicular morphology and function. Additionally, we investigated the effect of resistance exercise training (RT) on testicular parameters in PAH rats. Eight healthy Wistar rats and eight PAH rats were subjected to RT training for 30 days; the other PAH and healthy rats (n = 8/group) did not exercise. PAH rats had lower reproductive organ weight, serum testosterone levels, testicular glucose, and nitric oxide (NO) levels, Leydig cell parameters, tubular morphometry, germ cell counts, and daily sperm production than healthy animals did. The practice of RT attenuated the negative impact of PAH on the relative weights of the testes and epididymides, Leydig cell number, nuclear volume, testicular NO levels, and seminiferous epithelium architecture. Moreover, RT positively influenced testosterone levels in PAH animals. We conclude that PAH exerts deleterious effects on testicular histology and function. However, RT can be beneficial to the PAH-affected testicular parameters.