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Effect of Altitude on Respiratory Functional Status in COVID-19 Survivors: Results from a Latin American Cohort—FIRCOV

2023; Mary Ann Liebert, Inc.; Volume: 24; Issue: 1 Linguagem: Inglês

10.1089/ham.2022.0062

1557-8682

Laura Gochicoa‐Rangel, Santiago C. Arce, Carlos Aguirre-Franco, Wilmer Madrid-Mejía, Mónica Gutiérrez-Clavería, Lorena Noriega, Patricia Schönffeldt-Guerrero, Agustín Acuña, Arturo Cortés-Tellés, Luisa Martínez-Valdeavellano, Federico Isaac Hernández-Rocha, Omar Ceballos-Zúñiga, Rodrigo Del‐Río‐Hidalgo, Sonia Sánchez, Erika Meneses-Tamayo, Iván Chérrez-Ojeda, Luis Lozano-Martínez, Miriam López-López, Mónica Silva-Cerón, Isabel Salas-Escamilla, Adela Durán-Cuéllar, Carlos Guzmán-Valderrábano, Saúl Vázquez-López, Yuri Noemí Pou-Aguilar, Esperanza Figueroa‐Hurtado, Diana Lizbeth Ortíz‐Farias, Ricardo Coronado, Anna Meraz Wong, Amny Trujilo, Génesis Rodríguez, Edgardo Collao, Juan Céspedes, Patricia Sandoval, Jorge Espinoza, Silvia Civale, Mónica Rodríguez, Cecilia Oropeza, Giorsay Quezada, Edilzar González, Ester Miranda, Tomas Silva Arenas, Roberto Ivan, Ibarra Sanchez,

Chronic Obstructive Pulmonary Disease (COPD) Research

Laura Gochicoa-Rangel, Santiago C. Arce, Carlos Aguirre-Franco, Wilmer Madrid-Mejía, Mónica Gutiérrez-Clavería, Lorena Noriega-Aguirre, Patricia Schonffeldt-Guerrero, Agustín Acuña-Izcaray, Arturo Cortés-Telles, Luisa Martínez-Valdeavellano, Federico Isaac Hernández-Rocha, Omar Ceballos-Zúñiga, Rodrigo Del Rio Hidalgo, Sonia Sánchez, Erika Meneses-Tamayo, and Iván Chérrez-Ojeda; and on Behalf of the Respiratory Physiology Project in COVID-19 (FIRCOV). Effect of altitude on respiratory functional status in COVID-19 survivors: results from a Latin American Cohort-FIRCOV. High Alt Med Biol 24:37-48, 2023. Persistent symptoms and lung function abnormalities are common in COVID-19 survivors. Objectives: To determine the effect of altitude and other independent variables on respiratory function in COVID-19 survivors. Methods: Analytical, observational, cross-sectional cohort study done at 13 medical centers in Latin America located at different altitudes above sea level. COVID-19 survivors were invited to perform pulmonary function tests at least 3 weeks after diagnosis. Results: 1,368 participants (59% male) had mild (20%), moderate (59%), and severe (21%) disease. Restriction by spirometry was noted in 32%; diffusing capacity of the lung for carbon monoxide (DLCO) was low in 43.7%; and 22.2% walked less meters during the 6-minute walk test (6-MWT). In multiple linear regression models, higher altitude was associated with better spirometry, DLCO and 6-MWT, but lower oxygen saturation at rest and during exercise. Men were 3 times more likely to have restriction and 5.7 times more likely to have a low DLCO. Those who had required mechanical ventilation had lower DLCO and walked less during the 6-MWT. Conclusions: Men were more likely to have lower lung function than women, even after correcting for disease severity and other factors. Patients living at a higher altitude were more likely to have better spirometric patterns and walked farther but had lower DLCO and oxygen saturation.