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Serotype Distribution and Antimicrobial Resistance of Streptococcus agalactiae Isolates in Nonpregnant Adults with Streptococcal Toxic Shock Syndrome in Japan in 2014 to 2021

2023; American Society for Microbiology; Volume: 11; Issue: 2 Linguagem: Inglês

10.1128/spectrum.04987-22

2165-0497

Tadayoshi Ikebe, Rumi Okuno, Yumi Uchitani, Mami Takano, Takahiro Yamaguchi, Hitoshi Otsuka, Yu Kazawa, Shohei Fujita, Ayaka Kobayashi, Yoshimi Date, Junko Isobe, Emi Maenishi, Makoto Ohnishi, Yukihiro Akeda, Keiko Ogawa‐Ochiai, Kazuya Mitsuhashi, Takayuki Konno, Kaori Iwabuchi, Takuya Yamanaka, Junji Seto, Mikako Hosoya, Takuhiro Suto, Hiroo Sakai, I. Ogawa, Mayumi Ogawa, Ayano Horikoshi, Miki Matsuyama, Yusuke Yodotani, Chieko Goto, Junko Yoshihara, Kentaro Tomari, Fumie Suzuki, Sae Onoda, Asami Sekikawa, Miki Hikida, Mitsuru Kishizawa, Haruyoshi Kanagawa, Akira Wakatsuki, Akihito Kobayashi, Yuhki Nagai, Tatsuya MATSUDA, Higashi Ogura, Makiko Noda, Ayako Furuta, Emiko Kitagawa, Misa Yoshikawa, Mika Fujikawa, Etsuko Saito, Chikara Nakagawa, Noriko Nakanishi, Yuko Kiguchi, Kayoko Nakaoka, Kayo Aoki, Seiko Umehara, Ryutaro Murayama, Shoko Hirata, Kenkichi Hayashibara, Jun Kawase, Hisahiro Kawai, Takahiro Hiratsuka, Hiroko Akita, Chiiko Yoshida, Yuka Kakumiya, Yukiko Asano, Sayaka Osaki, Atsuko Kageyama, Yuji Migita, Yurika Furukawa, Rika Maeda, Etsuko Nakamura, Tetsuya Kakita, Tsuyoshi Kudeken,

Antimicrobial Resistance in Staphylococcus

The incidence of streptococcal toxic shock syndrome (STSS) due to group B Streptococcus (GBS) has been increasing annually in Japan and is becoming a serious challenge. Furthermore, in recent years, penicillin- or clindamycin-resistant strains used in treating streptococcal toxic shock syndrome have been reported. However, no report analyzed >100 isolates of group B Streptococcus causing streptococcal toxic shock syndrome. Therefore, we aimed to perform serotyping and antimicrobial susceptibility testing of 268 isolated group B Streptococcus strains from streptococcal toxic shock syndrome cases involving nonpregnant adult patients in Japan between 2014 and 2021. The most prevalent serotype was Ib, followed by serotypes V, III, and Ia. Seven isolates were resistant to penicillin G, and 17.9% (48 isolates) were resistant to clindamycin. Of the penicillin-resistant group B Streptococcus isolates, 71.4% (5 isolates) were clindamycin resistant. In addition, group B Streptococcus strains resistant to penicillin and clindamycin were isolated from patients with streptococcal toxic shock syndrome. Therefore, before these strains become prevalent, introduction of the group B Streptococcus vaccine is essential for disease prevention.