Produção Nacional
Revisado por pares
Chemical profile and cytotoxic evaluation of aerial parts of Euphorbia tirucalli L. on gastric adenocarcinoma (AGS cells)
2023; Taylor & Francis; Volume: 37; Issue: 24 Linguagem: Inglês
10.1080/14786419.2023.2179623
ISSN1478-6427
AutoresLarissa Silva de Souza, Cristina Luz Tosta, Jéssica Rodrigues Pereira de Oliveira Borlot, Marcia Cristina Braga Nunes Varricchio, Rodrigo Rezende Kitagawa, Paulo R. Filgueiras, Ricardo Machado Kuster,
Tópico(s)Tannin, Tannase and Anticancer Activities
ResumoEthanol extract from the aerial parts of Euphorbia tirucalli L. as well as the latex of the plant suspended in water are used by the Brazilian population for the treatment of various diseases, including cancer. The purposes of this study were to determine if the ethanol extract is effective as cytotoxic agent against gastric adenocarcinoma cells (AGS) and its chemical composition by GC-MS, ESI-(-)-FT-ICR MS and (-)-ESI-LTQ-MS/MS. The results were compared with that of latex previously described by us. Hexane and aqueous fractions showed higher cytotoxicity on AGS cells. Nine triterpene compounds were detected by GC-MS in hexane fraction, including euphol and friedelin, while ellagic acid was identified as main phenolic compound in aqueous extract. Therefore, the greater cytotoxic activity of the ethanol extract of the aerial parts of Euphorbia tirucalli for gastric cancer, when compared to latex, seems to originate from the antiproliferative effects of ellagic acid and triterpenes.
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