Visible-light-induced C(sp 3 )−H thiocyanation of pyrazolin-5-ones: a practical synthesis of 4-thiocyanated 5-hydroxy-1 H -pyrazoles
2023; Royal Society of Chemistry; Volume: 21; Issue: 10 Linguagem: Inglês
10.1039/d3ob00092c
ISSN1477-0539
AutoresXiu-Rong Hu, Haichang Guo, Huajiang Jiang, Renhua Zheng, Yaqin Zhou, Lei Wang,
Tópico(s)Catalytic C–H Functionalization Methods
ResumoA direct, aerobic and visible light photocatalytic approach to synthesize 4-thiocyanated 5-hydroxy-1H-pyrazoles via cross-coupling of pyrazolin-5-ones with ammonium thiocyanate is described. Under redox-neutral and metal-free conditions, a series of 4-thiocyanated 5-hydroxy-1H-pyrazoles could be easily and efficiently obtained in good to high yields by using low-toxicity and inexpensive ammonium thiocyanate as the thiocyanate source.
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