Antiandrogen Induced Cryptorchidism in the Pig is Associated with Failed Gubernacular Regression and Epididymal Malformations
1995; Lippincott Williams & Wilkins; Volume: 154; Issue: 2 Linguagem: Inglês
10.1016/s0022-5347(01)67109-x
ISSN1527-3792
AutoresDaniel R. McMahon, Stephen A. Kramer, Douglas A. Husmann,
Tópico(s)Urological Disorders and Treatments
ResumoNo AccessJournal of UrologyPediatric Urology1 Aug 1995Antiandrogen Induced Cryptorchidism in the Pig is Associated with Failed Gubernacular Regression and Epididymal Malformations Daniel R. McMahon, Stephen A. Kramer, and Douglas A.* Husmann Daniel R. McMahonDaniel R. McMahon More articles by this author , Stephen A. KramerStephen A. Kramer More articles by this author , and Douglas A.* HusmannDouglas A.* Husmann More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)67109-XAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Can antiandrogens cause cryptorchidism in an animal model with a strip-like gubernaculum? If so, what anatomical abnormalities are associated with cryptorchidism? Materials and Methods: Timed pregnant sows received the antiandrogen flutamide during defined gestational intervals. Fetal pigs were evaluated for the presence of testicular undescent and for morphological paratesticular abnormalities at 110 days of gestation (birth). Results: Of 180 testes 84 (47 percent) were undescended and 9 (5 percent) were in the abdominal cavity. No undescended testis (0 of 200 testes) was found in control animals (p less than 0.001). Epididymal anomalies were found in all intra-abdominal testes, which was significant when compared to the epididymal abnormalities found with inguinal undescended testes (0 percent) or descended testes (1 percent) (p less than 0.001). Alterations in gubernacular morphology, in particular failure of gubernacular regression, were also directly associated with cryptorchidism (p less than 0.001). Conclusions: Androgens partially control transabdominal and transinguinal descent of the porcine testis. In addition, antiandrogen induced cryptorchidism is associated with epididymal malformation and failure of gubernacular regression. 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Google Scholar Department of Urology, Mayo Clinic, Rochester, Minnesota.© 1995 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byCOSTA W, SAMPAIO F, FAVORITO L and CARDOSO L (2018) Testicular Migration: Remodeling of Connective Tissue and Muscle Cells in Human Gubernaculum TestisJournal of Urology, VOL. 167, NO. 5, (2171-2176), Online publication date: 1-May-2002.BARTHOLD J, KUMASI-RIVERS K, UPADHYAY J, SHEKARRIZ B and IMPERATO-MCGINLEY J (2018) TESTICULAR POSITION IN THE ANDROGEN INSENSITIVITY SYNDROME: IMPLICATIONS FOR THE ROLE OF ANDROGENS IN TESTICULAR DESCENTJournal of Urology, VOL. 164, NO. 2, (497-501), Online publication date: 1-Aug-2000.BARTHOLD J, KRYGER J, DERUSHA A, DUEL B, JEDNAK R and SKAFAR D (2018) EFFECTS OF AN ENVIRONMENTAL ENDOCRINE DISRUPTOR ON FETAL DEVELOPMENT, ESTROGEN RECEPTOR alpha AND EPIDERMAL GROWTH FACTOR RECEPTOR EXPRESSION IN THE PORCINE MALE GENITAL TRACTJournal of Urology, VOL. 162, NO. 3 Part 1, (864-871), Online publication date: 1-Sep-1999.Barthold J, Mahler H, Sziszak T and Newton B (2018) Lack of Feminization of the Cremaster Nucleus by Prenatal Flutamide Administration in the Rat and PigJournal of Urology, VOL. 156, NO. 2S, (767-771), Online publication date: 1-Aug-1996. Volume 154Issue 2August 1995Page: 553-557 Advertisement Copyright & Permissions© 1995 by American Urological Association, Inc.MetricsAuthor Information Daniel R. McMahon More articles by this author Stephen A. Kramer More articles by this author Douglas A.* Husmann More articles by this author Expand All Advertisement PDF downloadLoading ...
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