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Influence of antiresorptive/antiangiogenic therapy on the extension of experimentally induced peri-implantitis lesions

2023; Springer Nature; Volume: 27; Issue: 6 Linguagem: Inglês

10.1007/s00784-023-04904-8

1436-3771

Frank Schwarz, Kathrin Becker, Fanya Lukman, Katharina Melissa Müller, Victoria Sarabhai, Nicole Rauch, Robert Kerberger, Aušra Ramanauskaitė, Robert Sader, Karina Obreja,

Bone Metabolism and Diseases

To investigate the extension of experimentally induced peri-implantitis lesions under various antiresorptive and antiangiogenic medications.Fourty-eight albino rats had randomly received the following medications (dual application, n = 8 each): (1) amino-bisphosphonate (zoledronate) (Zo), (2) RANKL inhibitor (denosumab) (De), (3) antiangiogenic (bevacizumab) (Be), (4) Zo+Be, (5) De+Be, or (6) no medication (Co). Ligature- and lipopolysaccharide-induced peri-implantitis lesions were established at 2 maxillary implants over a period of 16 weeks. Histological (e.g., apical extension and surface area of the inflammatory cell infiltrate-aICT, ICT; defect length; defect width; CD68 positive cells) and bone micromorphometric (μCT) outcomes were assessed. The animal was defined as a statistical unit.A total of n = 38 animals (Zo = 6, De = 6, Be = 8, Zo + Be = 6, De + Be = 5, Co = 7) were analyzed. ICT's were commonly marked by a positive CD68 antigen reactivity. Comparable median aICT (lowest-Zo: 0.53 mm; highest-Be: 1.22 mm), ICT (lowest-De + Be: 0.00 mm2; highest-Co: 0.49 mm2), defect length (lowest-Zo: 0.90 mm; highest-Co: 1.93 mm) and defect width (lowest-De+Be: 1.27 mm; highest-Be: 1.80 mm) values were noted in all test and control groups. Within an inner (diameter: 0.8 mm) cylindric volume of interest, the bone microstructure did not significantly differ between groups.The present analysis did not reveal any marked effects of various antiresorptive/ antiangiogenic medications on the extension of experimentally induced peri-implantitis lesions.The extension of peri-implantitis lesions may not be facilitated by the antiresorptive and antiangiogenic medications investigated.