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Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder

2023; Elsevier BV; Volume: 245; Linguagem: Inglês

10.1016/j.drugalcdep.2023.109822

1879-0046

Anna Hernández‐Rubio, Arantza Sanvisens, Lucía Barbier‐Torres, Rafael Blanes, Laia Miquel, Marta Torrens, Gabriel Rubio, Ferrán Bolao, Paola Zuluaga, Daniel Fuster, Fernando Rodrı́guez de Fonseca, Magı́ Farré, Roberto Muga, CohRTA Study, Coordinating Center, Arantza Sanvisens, Paola Zuluaga, Daniel Fuster, Anna Hernández‐Rubio, Magı́ Farré, Esther Papasseit, Clara Pérez‐Mañá, Lourdes Poyatos, Nuria García‐Marchena, Enric Abellí, Roberto Muga, A.Rendle Short, Catalina Moranta, Rafael Blanes, Gabriel Rubio, Ana Sión, Laia Miquel, Lluïsa Ortega, Pol Bruguera, Elsa Caballería, Ana Messeguer, Marta Torrens, Francina Fonseca, Joan Ignasi Mestre-Pintó, María Alías, F. Dinamarca, Ferrán Bolao, Fernando Rodrı́guez de Fonseca, Francisco Javier Pavón, Pedro Araos, María Flores-López, Antonia Serrano, Miguel Marcos, Candelaria Martín, Onán Pérez‐Hernández, Jorge Manzanares, Lucía Illescas,

Bipolar Disorder and Treatment

Hypomagnesemia (hypoMg) has not yet been extensively studied in alcohol use disorder (AUD) . We hypothesize that chronic, excessive alcohol consumption favors oxidative stress and pro-inflammatory alterations that may be exacerbated by hypoMg. The objective of this study was to analyze the prevalence and associations of hypoMg in AUD.Cross-sectional study in patients admitted for a first treatment of AUD in six tertiary centers between 2013 and 2020. Socio-demographic, alcohol use characteristics, and blood parameters were ascertained at admission.753 patients (71% men) were eligible; age at admission was 48 years [IQR, 41-56 years]. Prevalence of hypoMg was 11.2%, higher than that observed for hypocalcemia (9.3%), hyponatremia (5.6%), and hypokalemia (2.8%). HypoMg was associated with older age, longer duration of AUD, anemia, higher erythrocyte sedimentation rate, gamma-glutamyl transpeptidase, glucose levels, advanced liver fibrosis (FIB-4 ≥3.25) and estimated glomerular filtration rate (eGFR) < 60 mL/min. In multivariate analysis, advanced liver fibrosis (OR, 8.91; 95% CI, 3.3-23.9) and eGFR < 60 mL (OR, 5.2; 95% CI, 1.0-26.2) were the only factors associated with hypoMg.Mg deficiency in AUD is associated with liver damage and glomerular dysfunction suggesting that both comorbidities should be assessed in the course of serum hypoMg.