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miRNAs role in cervical cancer pathogenesis and targeted therapy: Signaling pathways interplay

2023; Elsevier BV; Volume: 244; Linguagem: Inglês

10.1016/j.prp.2023.154386

1618-0631

Ahmed S. Doghish, Mohamed A. Ali, Salah S. Elyan, Mahmoud A. Elrebehy, Hend H. Mohamed, Reda Mansour, Ayatallah Elgohary, Aml Ghanem, Ahmed Hassan Ibrahim Faraag, Nourhan M. Abdelmaksoud, Hebatallah Ahmed Mohamed Moustafa,

Cervical Cancer and HPV Research

Cervical cancer (CC) is the primary cause of cancer deaths in underdeveloped countries. The persistence of infection with high-risk human papillomavirus (HPV) is a significant contributor to the development of CC. However, few women with morphologic HPV infection develop invasive illnesses, suggesting other mechanisms contribute to cervical carcinogenesis. MicroRNAs (miRNAs, miRs) are small chain nucleic acids that can regulate wide networks of cellular events. They can inhibit or degrade their target protein-encoding genes. They had the power to regulate CC's invasion, pathophysiology, angiogenesis, apoptosis, proliferation, and cell cycle phases. Further research is required, even though novel methods have been developed for employing miRNAs in the diagnosis, and treatment of CC. We'll go through some of the new findings about miRNAs and their function in CC below. The function of miRNAs in the development of CC and its treatment is one of these. Clinical uses of miRNAs in the analysis, prediction, and management of CC are also covered.