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Primary Localized Amyloidosis of The bladder:: Experience With Dimethyl Sulfoxide Therapy

2002; Lippincott Williams & Wilkins; Volume: 168; Issue: 3 Linguagem: Inglês

10.1016/s0022-5347(05)64564-8

1527-3792

Reza S. Malek, Dietlind L. Wahner‐Roedler, Morie A. Gertz, Robert A. Kyle,

Kidney Stones and Urolithiasis Treatments

No AccessJournal of UrologyCLINICAL UROLOGY: ORIGINAL ARTICLES1 Sep 2002Primary Localized Amyloidosis of The bladder:: Experience With Dimethyl Sulfoxide Therapy Reza S. Malek, Dietlind L. Wahner-Roedler, Morie A. Gertz, and Robert A. Kyle Reza S. MalekReza S. Malek More articles by this author , Dietlind L. Wahner-RoedlerDietlind L. Wahner-Roedler More articles by this author , Morie A. GertzMorie A. Gertz More articles by this author , and Robert A. KyleRobert A. Kyle More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)64564-8AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We present our long-term experience with intravesical dimethyl sulfoxide (DMSO) for primary localized amyloidosis of the bladder. Materials and Methods: The study included 4 males and 2 females 28 to 68 years old (mean age 54) at diagnosis of biopsy proven primary localized amyloidosis involving the bladder diffusely or extensively in 1 locale. All patients had normal upper urinary tracts. They continued to be symptomatic (hematuria in 3, irritative voiding symptoms in 1, and hematuria and irritative voiding symptoms in 2) despite conventional transurethral destructive therapy. Every 2 weeks they received 30-minute instillations of 50 ml. 50% DMSO intravesically for 3 months (patient 1), 6 months (1) and 1 year (4). Results: Therapy failed at 3 and 6 months in 2 patients of whom 1 with a contracted bladder underwent cystectomy and another was stabilized for 1 year with laser therapy. In the remaining 4 patients who were followed for 6 years disease stabilized for 2 to 6 years (mean 3.5) but 3 later required additional therapy including repeat DMSO in 1 and laser therapy in 2. 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