Fighting Antimicrobial Resistance in Neonatal Intensive Care Units: Rational Use of Antibiotics in Neonatal Sepsis
2023; Multidisciplinary Digital Publishing Institute; Volume: 12; Issue: 3 Linguagem: Inglês
10.3390/antibiotics12030508
ISSN2079-6382
AutoresDimitrios Rallis, Vasileios Giapros, Anastasios Serbis, Chrysoula Kosmeri, Maria Baltogianni,
Tópico(s)Sepsis Diagnosis and Treatment
ResumoAntibiotics are the most frequently prescribed drugs in neonatal intensive care units (NICUs) due to the severity of complications accompanying neonatal sepsis. However, antimicrobial drugs are often used inappropriately due to the difficulties in diagnosing sepsis in the neonatal population. The reckless use of antibiotics leads to the development of resistant strains, rendering multidrug-resistant pathogens a serious problem in NICUs and a global threat to public health. The aim of this narrative review is to provide a brief overview of neonatal sepsis and an update on the data regarding indications for antimicrobial therapy initiation, current guidance in the empirical antimicrobial selection and duration of therapy, and indications for early discontinuation.
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