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Seroprevalence trends of anti-SARS-CoV-2 antibodies and associated risk factors: a population-based study

2023; Springer Science+Business Media; Volume: 51; Issue: 5 Linguagem: Inglês

10.1007/s15010-023-02011-0

1439-0973

Stefano Tancredi, Arnaud Chioléro, Cornelia Wagner, Moa Lina Haller, Patricia Chocano-Bedoya, Natalia Ortega, Nicolas Rodondi, Marco Kaufmann, Elsa Lorthe, Hélène Baysson, Silvia Stringhini, Gisela Michel, Chantal Lüdi, E Harju, Irène Frank, Medea Imboden, Melissa Witzig, Dirk Keidel, Nicole Probst‐Hensch, Rebecca Amati, Emiliano Albanese, Laurie Corna, Luca Crivelli, Julia Vincentini, Semira Gonseth, Murielle Bochud, Valérie D’Acremont, Philipp Köhler, Christian R. Kahlert, Alexia Cusini, Anja Frei, Milo A. Puhan, Marco Geigges, Marco Kaufmann, Jan Fehr, Stéphane Cullati, Antonio Amendola, A Anagnostopoulos, Daniela Anker, Anna Maria Annoni, Hélène E. Aschmann, Andrew S. Azman, Antoine Bal, Tala Ballouz, Kleona Bezani, Annette Blattmann, Patrick Bleich, Patrick Bodenmann, Peter Buttaroni, Audrey Butty, Anne-Linda Camerini, Patricia Chocano-Bedoya, Prune Collombet, Diana Sofia Da Costa Santos, Agathe Deschamps, Paola D’Ippolito, Anja Domenghino, Richard Dubos, Roxane Dumont, Olivier Duperrex, Julien Dupraz, Malik Egger, Emna El-May, Nacira El Merjani, Nathalie Engler, Adina Mihaela Epure, Lukas Erksam, Sandrine Estoppey, Marta Fadda, Vincent Faivre, Andrea Felappi, Maddalena Fiordelli, Antoine Flahault, Luc Fornerod, Cristina Fragoso Corti, Natalie Francioli, Marion Frangville, Irène Frank, Giovanni Franscella, Clément Graindorge, Idris Guessous, Séverine Harnal, Emilie Jendly, Ayoung Jeong, Laurent Kaiser, Simone Kessler, Christine Krähenbühl, Susi Kriemler, Julien Lamour, Sara Levati, Pierre Lescuyer, Andrea Loizeau, Chantal Luedi, Jean‐Luc Magnin, Chantal Martinez, Éric Masserey, Dominik Menges, Rosalba Morese, Nicolai Mösli, Natacha Noël, Daniel H. Paris, Jérôme Pasquier, Francesco Pennacchio, Stefan M. Pfister, Giovanni Piumatti, Géraldine Poulain, Caroline Pugin, Milo A. Puhan, Nick Pullen, Thomas Radtke, Manuela Rasi, Aude Richard, Viviane Richard, Claude-François Robert, Pierre‐Yves Rodondi, Serena Sabatini, Khadija Samir, Javier Sanchis Zozaya, Virginie Schlüter, Alexia Schmid, Valentine Schneider, Maria Schüpbach, Nathalie Schwab, Claire Semaani, Alexandre Speierer, Amélie Steiner-Dubuis, Stéphanie Testini, Julien Thabard, Mauro Tonolla, Nicolas Troillet, Agnė Ulytė, Sophie Vassaux, Thomas Vermes, Jennifer Villers, Viktor von Wyl, Rylana Wenger, Erin West, Ania Wisniak, María-Eugenia Zaballa, Kyra D. Zens, Claire Zuppinger,

COVID-19 epidemiological studies

We aimed to assess the seroprevalence trends of SARS-CoV-2 antibodies in several Swiss cantons between May 2020 and September 2021 and investigate risk factors for seropositivity and their changes over time.We conducted repeated population-based serological studies in different Swiss regions using a common methodology. We defined three study periods: May-October 2020 (period 1, prior to vaccination), November 2020-mid-May 2021 (period 2, first months of the vaccination campaign), and mid-May-September 2021 (period 3, a large share of the population vaccinated). We measured anti-spike IgG. Participants provided information on sociodemographic and socioeconomic characteristics, health status, and adherence to preventive measures. We estimated seroprevalence with a Bayesian logistic regression model and the association between risk factors and seropositivity with Poisson models.We included 13,291 participants aged 20 and older from 11 Swiss cantons. Seroprevalence was 3.7% (95% CI 2.1-4.9) in period 1, 16.2% (95% CI 14.4-17.5) in period 2, and 72.0% (95% CI 70.3-73.8) in period 3, with regional variations. In period 1, younger age (20-64) was the only factor associated with higher seropositivity. In period 3, being aged ≥ 65 years, with a high income, retired, overweight or obese or with other comorbidities, was associated with higher seropositivity. These associations disappeared after adjusting for vaccination status. Seropositivity was lower in participants with lower adherence to preventive measures, due to a lower vaccination uptake.Seroprevalence sharply increased over time, also thanks to vaccination, with some regional variations. After the vaccination campaign, no differences between subgroups were observed.