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Cytokines and pancreatic cancer

1989; Humana Press; Volume: 4; Issue: 3 Linguagem: Inglês

10.1007/bf02938466

2363-5134

Jörn‐Sven Kühl, Rüdiger Klapdor, M Bahlo, Norman Franke, C. Kunde, H. Arps, Manfred Dietel,

Cancer, Stress, Anesthesia, and Immune Response

Ten xenotransplants of human gastrointestinal carcinomas (eight human pancreatic carcinomas) were assayed for their sensitivity to human rIFN-7 and human rTNF-a in nude mice. Both substances demonstrated a dose and route dependent antitumoral activity in principle. However, the extent of response varied distinctly between the tested xenografts. rTNF-a was clearly superior to rIFN-γ at systemic application of comparable doses (0.8 mg/kg/d). Intramural administration of both cytokines could cause cytotoxic effects and was significantly more effective than systemic administration that predominantly resulted in antiproliferation. Growth inhibition of rIFN-γ or rTNF-α alone could be clearly enhanced by combining both cytokines. In addition, the results suggest: the possibility to enhance the effects of rIFN-γ alone also by combination with nIL 2, as well as a decrease of the effects of rTNF-a with time of therapy.