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Massive Splenomegaly and Epstein-Barr Virus-Associated Infectious Mononucleosis in a Patient With Gaucher Disease

1999; Lippincott Williams & Wilkins; Volume: 21; Issue: 1 Linguagem: Inglês

10.1097/00043426-199901000-00010

1536-3678

Mary Eapen, Margaret K. Hostetter, Joseph P. Neglia,

Autoimmune and Inflammatory Disorders Research

Purpose: Gaucher disease should be considered in the differential diagnosis of a patient with Epstein-Barr virus (EBV) infection who has unexplained or disproportionate splenomegaly. Patients and Methods: A previously asymptomatic adolescent with EBV-associated infectious mononucleosis and massive splenomegaly is described. He was found to have Gaucher disease on bone marrow biopsy, which was performed to exclude a hematologic malignancy. The diagnosis was confirmed by assay of β-glucosidase enzyme activity. Results: Regression of splenomegaly and improving hematologic indices. Conclusion: Patients with infectious mononucleosis and disproportionate organomegaly should be investigated to exclude a hematologic malignancy or an underlying storage disorder such as Gaucher disease.