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Parâmetros hematológicos negligenciados com influência no prognóstico da insuficiência cardíaca – resultados do estudo REFERENCE

2022; Sociedade Galega de Medicina Interna; Volume: 83; Issue: 2 Linguagem: Inglês

10.22546/65/2413

1989-3922

M�RIO BARBOSA, ANDREIA MATOS, MANUEL BICHO, Luiz Menezes Falcão,

Central Venous Catheters and Hemodialysis

Aims: In heart failure patients, anemia and iron deficiency are predictors of poor outcome.We studied the association of anemia, iron deficiency and related hematological parameters with short-term rehospitalization, short-term all-cause mortality and end of follow-up all-cause mortality in heart failure patients.Material and Methods: Anemia, iron deficiency, red cell distribution width and erythropoietin were assessed in patients hospitalized with acute decompensated heart failure.Univariate Cox proportional hazard model was used to assess the relationship between variables and outcomes.Results: 65 patients were followed for a median of 13.7 (Q1-Q3 6.7-18.9)months.Mean age was 79.2 (SD 10.8) years.The mean left ventricular ejection fraction was 50.38 ± 19.07 %.Variables associated with an increased risk for short-term rehospitalization were red cell distribution width (HR 1.35; 95% CI 1.16-1.58),anemia (HR 3.81; 95% CI 1.29-11.28)and anemia with iron deficiency (HR 3.50; 95% CI 1.30-9.38).Increased risk for short-term mortality was associated with red cell distribution width (HR 1.83; 95% CI 1.29-2.59),erythropoietin (HR 1.38; 95% CI 1.04-1.82),absolute iron deficiency (HR 7.22; 95% CI 1.50-34.81)and anemia with iron deficiency (HR 4.48; 95% CI 1.26-15.88).Variables associated with increased risk for end of follow-up mortality were red cell distribution width (HR 1.31; 95% CI 1.12-1.54)and erythropoietin (HR 1.29; 95% CI 1.11-1.49).Conclusions: Conclusions: Anemia and red cell distribution width correlated with higher risk for short-term rehospitalization.Absolute iron deficiency, red cell distribution width and erythropoietin were associated with higher risk for short-term mortality.Red cell distribution width and erythropoietin were associated with higher risk for end of follow-up mortality.