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Psychiatric onset of prodromal dementia with Lewy bodies: Current insights into neuroimaging tools

2023; Taylor & Francis; Volume: 24; Issue: 7 Linguagem: Inglês

10.1080/15622975.2023.2191008

1814-1412

Niels Hansen, Sebastian Johannes Müller, Eya Khadhraoui, Marielle Ernst, Christian Heiner Riedel, Jens Wiltfang, Claudia Lange, Carolin Bouter,

Alzheimer's disease research and treatments

AbstractPurpose Our article is dedicated to describing the state-of-the-art in imaging techniques for assessing prodromal dementia with Lewy bodies (pro-DLB) with a psychiatric-onset.Materials and methods Imaging biomarker techniques are discussed.Results (123)-I-2-ß-carbomethoxy-3ß-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single photon emission computed tomography (123I-FP-CIT SPECT) seems to be a promising method as it reveals abnormalities in pro-DLB with a psychiatric-onset. New potential biomarkers can be revealed via novel techniques, such as manual segmentation in magnetic resonance imaging (MRI), which helps detect atrophy of the substantia innominata in pro-DLB with a psychiatric-onset as opposed to an onset with mild cognitive impairment (MCI). FDG-PET can also help us distinguish patients with mixed pro-DLB from those pro-DLB patients with a psychiatric-onset or MCI-onset. Changes in large-scale networks in the posterior standard mode and in attentional networks could be early signs in resting-state functional MRI to characterise pro-DLB.Conclusions In conclusion, there is a wide range of techniques that need to be explored in large-scale studies and are of promising value in understanding pro-DLB with a psychiatric-onset.Keywords: Prodromal dementia with Lewy bodiesneuroimagingbiomarkerspsychiatrysubstantia innominate AcknowledgementsWe thank Carole Cürten for editing and proofreading the English language in this manuscript.Author contributionsNH wrote the manuscript. All other authors revised the manuscript for important intellectual content.Statement of interestNone to declare.Additional informationFundingJW is supported by an Ilídio Pinho professorship, iBiMED (UIDB/04501/2020) at the University of Aveiro, Portugal. Funding was obtained from the Open Access fund of the University of Göttingen.