Portal de Periódicos da CAPES

Serologic responses to COVID-19 vaccination in children with history of multisystem inflammatory syndrome (MIS-C)

2023; Elsevier BV; Volume: 41; Issue: 17 Linguagem: Inglês

10.1016/j.vaccine.2023.03.021

1873-2518

Maria A. Perez, Hui‐Mien Hsiao, Xuemin Chen, Amber Kunkel, Nadine Baida, Laila Hussaini, Austin Lu, Carol Kao, Federico R. Laham, David A. Hunstad, Yajira Beltran, Teresa A. Hammett, Shana Godfred‐Cato, Ann Chahroudi, Evan J. Anderson, Ermias D. Belay, Christina A. Rostad,

Heparin-Induced Thrombocytopenia and Thrombosis

Understanding the serological responses to COVID-19 vaccination in children with history of MIS-C could inform vaccination recommendations. We prospectively enrolled seven children hospitalized with MIS-C and measured SARS-CoV-2 binding IgG antibodies to spike protein variants longitudinally pre- and post-Pfizer-BioNTech BNT162b2 primary series COVID-19 vaccination. We found that SARS-CoV-2 variant cross-reactive IgG antibodies variably waned following acute MIS-C, but were significantly boosted with vaccination and maintained for up to 3 months. We then compared post-vaccination binding, pseudovirus neutralizing, and functional antibody-dependent cell-mediated cytotoxicity (ADCC) titers to the reference strain (Wuhan-hu-1) and Omicron variant (B.1.1.529) among previously healthy children (n = 16) and children with history of MIS-C (n = 7) or COVID-19 (n = 8). Despite the breadth of binding antibodies elicited by vaccination in all three groups, pseudovirus neutralizing and ADCC titers were significantly reduced to the Omicron variant.