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Association of Mitochondrial DNA Copy Number With Brain MRI Markers and Cognitive Function

2023; Lippincott Williams & Wilkins; Volume: 100; Issue: 18 Linguagem: Inglês

10.1212/wnl.0000000000207157

1526-632X

Yuankai Zhang, Xue Liu, Kerri L. Wiggins, Nuzulul Kurniansyah, Xiuqing Guo, Amanda Rodrigue, Wei Zhao, Lisa R. Yanek, Scott M. Ratliff, Achilleas Pitsillides, Juan Sebastian Aguirre Patiño, Tamar Sofer, Dan E. Arking, Thomas R. Austin, Alexa S. Beiser, John Blangero, Eric Boerwinkle, Jan Bressler, Joanne E. Curran, Lifang Hou, Timothy M. Hughes, Sharon L.R. Kardia, Lenore J. Launer, Daniel Levy, Thomas H. Mosley, Ilya M. Nasrallah, Stephen S. Rich, Jerome I. Rotter, Sudha Seshadri, Wassim Tarraf, Kevin A. González, Ramachandran S. Vasan, Kristine Yaffe, Paul Nyquist, Bruce M. Psaty, Charles DeCarli, Jennifer A. Smith, David C. Glahn, Héctor M. González, Joshua C. Bis, Myriam Fornage, Susan R. Heckbert, Annette L. Fitzpatrick, Chunyu Liu, Claudia L. Satizábal, N. Aguilera, Seth A. Ament, Farah Ammous, Donna K. Arnett, Diane M. Becker, Joshua C. Bis, Elizabeth Blue, Eric Boerwinkle, Camille Breaux, Jan Bressler, Dima Chaar, MHI, Danielle Clarkson-Townsend, Brigidann Cooper, Josef Coresh, Adolfo Correa, Anita L. DeStefano, Jingzhong Ding, David W. Fardo, Annette L. Fitzpatrick, Myriam Fornage, Jennifer French, David C. Glahn, Héctor M. González, Einat Granot‐Hershkovitz, Patrick J. Hanly, Kathleen M. Hayden, Susan R. Heckbert, Scott Heemann, Steve Horvath, Karin F. Hoth, Timothy M. Hughes, Sidd Jaiswal, Xueqiu Jian, Yuriko Katsumata, Minjung Kho, Charles Kooperberg, Lenore J. Launer, Honghuang Lin, Elizabeth Litkowski, W. T. Longstreth, Alexandra Martin, Richard Mayeux, Julie Mikulla, Amy Miller, Biswapriya B. Misra, Thomas H. Mosley, Paul Nyquist, Jeff O’Connell, Michael Olivier, Gina M. Peloso, James A. Perry, Bruce M. Psaty, Shaun Purcell, Laura M. Raffield, Yugandi Ranaweera, Alex P. Reiner, Jerome I. Rotter, Muralidharan Sargurupremraj, Chloé Sarnowski, Claudia L. Satizábal, Gerard Schellenberg, Bonnie L Schoenbein, Sudha Seshadri, Lincoln MP Shade, Meghan I. Short, Jeannette Simino, Jennifer A. Smith, M. Smith, Sylvia Smoller, Beverly Snively, Rachel Soemedi, Sophie Sokolow, Daune Thorington, Timothy A. Thornton, Lisa R. Yanek, Qiong Yang, Miao Yu, Habil Zare, Wei Zhao, Gonçalo R. Abecasis, Avinash Abhyankar, Micheala A. Aldred, Dan E. Arking, Allison E. Ashley‐Koch, Abraham Aviv, Kathleen Barnes, Emily Barron‐Casella, Stephanie L. Battle, Thomas W. Blackwell, Deepika Burkardt, Christina A. Castellani, Suzy Comhair, Brigidann Cooper, Adolfo Correa, Phyllis Crockett, Mariza de Andrade, Dawn L. DeMeo, Maria Rizzo DePaoli, Jun Ding, Christine Dobski, Serpil C. Erzurum, Samar Farha, Jessica L. Fetterman, Caitlin Floyd, Mao Fu, Amber Gist, Einat Granot‐Hershkovitz, C. Charles Gu, Scott Heemann, Ryan D. Hernandez, Yun Soo Hong, Yi‐Hsiang Hsu, Anne E. Justice, Leslie A. Lange, Dan Levy, Honghuang Lin, Chunyu Liu, Ryan J. Longchamps, Jiantao Ma, JoAnn Manson, Tammy Markus, Merry‐Lynn McDonald, Stephen T. McGarvey, Julie Mikulla, Courtney G. Montgomery, Rajeeva Musunuri, Jeff O’Connell, Richard Oppong, Nathan Pankratz, Yong Qian, Jerome I. Rotter, Jessica R Shaw, Albert V. Smith, Tamar Sofer, Elizabeth A. Streeten, Weihong Tang, Kent D. Taylor, Marilyn J. Telen, Shelby Thompson, Daune Thorington, Hemant K. Tiwari, Ann Walsh, Emily S. Wan, Cuicui Wang, Heming Wang, Penglong Wang, B. S. Weir, L. Keoki Williams, James G. Wilson, Shujie Xiao, Weiling Xu, Yu‐Chung Yang, Wei Zhao,

Metabolomics and Mass Spectrometry Studies

Previous studies suggest that lower mitochondrial DNA (mtDNA) copy number (CN) is associated with neurodegenerative diseases. However, whether mtDNA CN in whole blood is related to endophenotypes of Alzheimer disease (AD) and AD-related dementia (AD/ADRD) needs further investigation. We assessed the association of mtDNA CN with cognitive function and MRI measures in community-based samples of middle-aged to older adults.