Developmental Renal Physiology of the Low Birth Weight Pre-Term Newborn
1996; Lippincott Williams & Wilkins; Volume: 156; Issue: 2S Linguagem: Inglês
10.1016/s0022-5347(01)65794-x
ISSN1527-3792
Autores Tópico(s)Infant Nutrition and Health
ResumoNo AccessJournal of UrologyAmerican Urological Association Guest Lecture1 Aug 1996Developmental Renal Physiology of the Low Birth Weight Pre-Term Newborn Robert L. Chevalier Robert L. ChevalierRobert L. Chevalier View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65794-XAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The remarkable growth of the kidney and the rapid changes in renal function in the second half of gestation and early postnatal period are discussed. Materials and Methods: Adaptation to the extrauterine environment involves immediate postnatal natriuresis that is prolonged in the pre-term neonate, followed by the sodium retention necessary for growth. Glomerular filtration rate increases throughout the postnatal period, and it is modulated by the renin-angiotensin system and prostaglandins. Because of this, the fetus and neonate are particularly susceptible to renal injury following the administration of angiotensin converting enzyme inhibitors or nonsteroidal anti-inflammatory drugs. Renal tubular function in the neonate is characterized by reduced renal concentration and acidification ability, which can be further compromised by obstructive uropathy. Urine calcium excretion is high in the neonate, which can be aggravated by calciuric drugs, such as furosemide and glucocorticoids. Results: Reduced renal mass results in compensatory renal growth even in the fetus, a response that could prove maladaptive later in life through excessive glomerular hyperfiltration and progressive interstitial fibrosis. Conclusions: These factors underscore the importance of attempting to maximize functional renal mass in the neonate or infant with renal impairment of any etiology. References 1 : Measurement of fetal urine production in normal pregnancy by real-time ultrasonography. Amer. J. 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Google Scholar From the Department of Pediatrics, Children's Medical Center, University of Virginia, Charlottesville, Virginia.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byNARASIMHAN K, KAUR B, CHOWDHARY S and BHALLA A (2018) DOES MODE OF TREATMENT AFFECT THE OUTCOME OF NEONATAL POSTERIOR URETHRAL VALVES?Journal of Urology, VOL. 171, NO. 6 Part 1, (2423-2426), Online publication date: 1-Jun-2004.GHALI A, EL MALKI T, SHEIR K, ASHMALLAH A and MOHSEN T (2018) POSTERIOR URETHRAL VALVES WITH PERSISTENT HIGH SERUM CREATININE: THE VALUE OF PERCUTANEOUS NEPHROSTOMYJournal of Urology, VOL. 164, NO. 4, (1340-1344), Online publication date: 1-Oct-2000.Tietjen D, Gloor J and Husmann D (2018) Proximal Urinary Diversion in the Management of Posterior Urethral Valves: Is it Necessary?Journal of Urology, VOL. 158, NO. 3, (1008-1010), Online publication date: 1-Sep-1997. Volume 156Issue 2SAugust 1996Page: 714-719 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Robert L. Chevalier More articles by this author Expand All Advertisement PDF downloadLoading ...
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