Portal de Periódicos da CAPES

Immuno-epigenetic signature derived in saliva associates with the encephalopathy of prematurity and perinatal inflammatory disorders

2023; Elsevier BV; Volume: 110; Linguagem: Inglês

10.1016/j.bbi.2023.03.011

1090-2139

Eleanor L.S. Conole, Kadi Vaher, Manuel Blesa, Gemma Sullivan, Anna J. Stevenson, Jill Hall, Lee Murphy, Michael J. Thrippleton, Alan J. Quigley, Mark E. Bastin, Véronique E. Miron, Heather C. Whalley, Riccardo E. Marioni, James P. Boardman, Simon R. Cox,

Infant Nutrition and Health

Preterm birth is closely associated with a phenotype that includes brain dysmaturation and neurocognitive impairment, commonly termed Encephalopathy of Prematurity (EoP), of which systemic inflammation is considered a key driver. DNA methylation (DNAm) signatures of inflammation from peripheral blood associate with poor brain imaging outcomes in adult cohorts. However, the robustness of DNAm inflammatory scores in infancy, their relation to comorbidities of preterm birth characterised by inflammation, neonatal neuroimaging metrics of EoP, and saliva cross-tissue applicability are unknown.