Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders
2023; Volume: 1; Issue: 3 Linguagem: Inglês
10.1038/s44220-023-00034-y
ISSN2731-6076
AutoresAlexander S. Hatoum, Sarah M. C. Colbert, Emma C. Johnson, Spencer B. Huggett, Joseph D. Deak, Gita A. Pathak, Mariela Jennings, Sarah E. Paul, Nicole R. Karcher, Isabella Hansen, David A. A. Baranger, Alexis C. Edwards, Andrew D. Grotzinger, Daniel E. Adkins, Amy Adkins, Mervi Alanne-Kinnunen, Jeffry Alexander, Fazil Alıev, Silviu‐Alin Bacanu, Anthony Batzler, Joanna M. Biernacka, Laura J. Bierut, Tim B. Bigdeli, А. С. Благонравова, Jason D. Boardman, Joseph M. Boden, Dorret I. Boomsma, Sandra A. Brown, Kathleen K. Bucholz, Danfeng Chen, Li‐Shiun Chen, Doo‐Sup Choi, S. Patricia Chou, Sven Cichon, William Copeland, Robin P. Corley, Franziska Degenhardt, Marta Di Forti, Nancy Diazgranados, Danielle M. Dick, Benjamin W. Domingue, Johan G. Eriksson, Lindsay A. Farrer, Jerome C. Foo, Tatiana Foroud, Louis Fox, Josef Frank, Mark A. Frye, Wolfgang Gäebel, Raul R. Gainetdinov, Ina Giegling, Nathan A. Gillespie, Alison Goate, David Goldman, Scott D. Gordon, Laura M. Hack, Dana B. Hancock, Kathleen Mullan Harris, Annette M. Hartmann, Andrew C. Heath, Stefanie Heilmann‐Heimbach, Stefan Herms, Victor Hesselbrock, John K. Hewitt, Ian B. Hickie, Colin A. Hodgkinson, Per Hoffmann, Christian J. Hopfer, L. John Horwood, Jouke‐Jan Hottenga, Daniel P. Howrigan, William G. Iacono, Marcus Ising, Eric O. Johnson, Jaakko Kaprio, Victor M. Karpyak, Kenneth S. Kendler, Martin A. Kennedy, Margaret A. Keyes, А.О. Кибитов, Falk Kiefer, Bettina Konte, John R. Kramer, Kenneth Krauter, Evgeny Krupitsky, Samuel Kuperman, Jari Lahti, Marius Lahti‐Pulkkinen, Dongbing Lai, Аnastasia Levchenko, Lannie Ligthart, Penelope A. Lind, Susanne Lucae, Michael T. Lynskey, Pamela A. F. Madden, Hermine H. Maes, Patrik K. E. Magnusson, Brion S. Maher, Karl Mann, Satu Männistö, Nicholas G. Martin, Hamdi Mbarek, Matt McGue, Matthew B. McQueen, Sarah E. Medland, Jacquelyn L. Meyers, Grant W. Montgomery, Bertram Müller‐Myhsok, Benjamin M. Neale, Elliot C. Nelson, Markus M. Nöthen, John I. Nürnberger, Aarno Palotie, Teemu Palviainen, John F. Pearson, Nancy L. Pedersen, Brenda W.J.H. Penninx, Roseann E. Peterson, Bernice Porjesz, Ulrich W. Preuss, Diego Quattrone, Katri Räikkönen, Maureen Reynolds, John P. Rice, Monika Ridinger, Marcella Rietschel, Brien P. Riley, Samuli Ripatti, Richard J. Rose, Dan Rujescu, Ksenia V. Rybakova, Euijung Ryu, Nancy L. Saccone, Jessica E. Salvatore, Norbert Scherbaum, Marc A. Schuckit, Melanie L. Schwandt, Pei‐Hong Shen, Richard Sherva, Judy L. Silberg, Michael C. Stallings, Dan J. Stein, Fabian Streit, Jana Strohmaier, Ralph E. Tarter, Nathaniel Thomas, Michael M. Vanyukov, Scott Vrieze, Tamara L. Wall, Raymond K. Walters, Bradley T. Webb, Robbee Wedow, Frank R. Wendt, Leah Wetherill, John B. Whitfield, Stephanie H. Witt, Norbert Wodarz, Margaret J. Wright, Sarah M. Hartz, Stephanie Zellers, Haitao Zhang, Hongyu Zhao, Hang Zhou, Peter Zill, Lea Zillich, Elliot M. Tucker‐Drob, Henry R. Kranzler, Lea K. Davis, Sandra Sanchez‐Roige, Renato Polimanti, Joel Gelernter, Howard J. Edenberg, Ryan Bogdan, Arpana Agrawal,
Tópico(s)Alcohol Consumption and Health Effects
ResumoGenetic liability to substance use disorders can be parsed into loci that confer general or substance-specific addiction risk. We report a multivariate genome-wide association meta-analysis that disaggregates general and substance-specific loci for published summary statistics of problematic alcohol use, problematic tobacco use, cannabis use disorder, and opioid use disorder in a sample of
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