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Clinical presentation and prognosis of COVID-19 in older adults with hypothyroidism: data from the GeroCovid observational study

2023; Springer Science+Business Media; Volume: 46; Issue: 9 Linguagem: Inglês

10.1007/s40618-023-02048-w

1720-8386

Viviana Bagalà, Antonello Sala, Caterina Trevisan, Chukwuma Okoye, Raffaele Antonelli Incalzi, Fabio Monzani, Stefano Volpato, Rachele Antognoli, Raffaele Antonelli Incalzi, M Antonietti, Viviana Bagalà, Giulia Bandini, Giuseppe Bellelli, Enrico Benvenuti, Marina Bergamin, Marco Bertolotti, Carlo Biagini, Angelo Bianchetti, Alessandra Bianchi, Mariangela Bianchi, Silvia Bignamini, Damiano Blandini, Stefano Boffelli, Maura Bugada, Valeria Calsolaro, Donatella Calvani, Giovanna Elisiana Carpagnano, Barbara Carrieri, Viviana Castaldo, Alessandro Cavarape, Ilaria Cazzulani, Carilia Celesti, Chiara Ceolin, Maria Giorgia Ceresini, Antonio Cherubini, Anita Chizzoli, Erika Ciarrocchi, Paola Cicciomessere, Alessandra Coin, Annalisa Corsi, Carlo Custodero, Federica D’Agostino, Maria Maddalena D’Errico, Aurelio De Iorio, Alessandro De Marchi, Giovambattista Desideri, Evelyn Di Matteo, Emma Espinosa, Luigi Esposito, Chiara De Fazio, Chiara Filippini, Lucia Fiore, Caterina Fontana, Lina Forte, Riccardo Franci Montorzi, Carlo Fumagalli, Stefano Fumagalli, Pietro Gareri, Antonella Giordano, Evelina Giuliani, Antonio Greco, Andrea Herbst, Giuseppe Ielo, Antonella La Marca, Umberto La Porta, Ilaria Lazzari, Diana Lelli, Yari Longobucco, Flaminia Lucchini, Daniela Lucente, Lorenzo Maestri, Marcello Maggio, Paola Mainquà, Alessandra Marengoni, Benedetta Martin, Valentina Massa, Liliana Mazza, Carmela Mazzoccoli, Fabio Monzani, Enrico Mossello, Federica Morellini, Chiara Mussi, Chukwuma Okoye, Giuseppe Orio, Annalisa Paglia, Giulia Pelagalli, Laura Pelizzoni, Alessandro Picci, Anette Hylen Ranhoff, Francesca Remelli, Onofrio Resta, Antonella Riccardi, Daniela Rinaldi, Renzo Rozzini, Carlo Sabbà, Leonardo Sacco, Mariateresa Santoliquido, Mariella Savino, Francesco Scarso, Giuseppe Sergi, Gaetano Serviddio, Chiara Sidoli, Vincenzo Solfrizzi, Benedetta Soli, Laura Tafaro, Andrea Tedde, Giuseppe Dario Testa, Maria Giulia Tinti, Francesco Tonarelli, Elisabetta Tonon, Caterina Trevisan, Aurora Vitali, Stefano Volpato, Francesca Zoccarato, Sonia Zotti,

Vitamin D Research Studies

The prevalence of hypothyroidism among older patients hospitalized for COVID-19 and its association with mortality is unclear. This study aims to investigate the prevalence of hypothyroidism in older COVID-19 inpatients and verify if this comorbidity is associated with a specific pattern of onset symptoms and a worse prognosis.COVID-19 inpatients aged ≥ 60 years, participating in the GeroCovid acute wards cohort, were included. The history of hypothyroidism was derived from medical records and the use of thyroid hormones. Sociodemographic data, comorbidities, symptoms/signs at the disease onset and inflammatory markers at ward admission were compared between people with vs without history of hypothyroidism. The association between hypothyroidism and in-hospital mortality was tested through Cox regression.Of the 1245 patients included, 8.5% had a history of hypothyroidism. These patients were more likely to present arterial hypertension and obesity compared with those without an history of hypothyroidism. Concerning COVID-19 clinical presentation, patients with hypothyroidism had less frequently low oxygen saturation and anorexia but reported muscle pain and loss of smell more commonly than those without hypothyroidism. Among the inflammatory markers, patients with hypothyroidism had higher lymphocytes values. At Cox regression, hypothyroidism was associated with reduced in-hospital mortality only in the univariable model (HR = 0.66, 95% CI 0.45-0.96, p = 0.03); conversely, no significant result were observed after adjusting for potential confounders (HR = 0.69, 95% CI 0.47-1.03, p = 0.07).Hypothyroidism does not seem to substantially influence the prognosis of COVID-19 in older people, although it may be associated with peculiar clinical and biochemical features at the disease onset.