Revisão Acesso aberto Produção Nacional Revisado por pares

Collagen supplementation in skin and orthopedic diseases: A review of the literature

2023; Elsevier BV; Volume: 9; Issue: 4 Linguagem: Inglês

10.1016/j.heliyon.2023.e14961

ISSN

2405-8440

Autores

Luana Dias Campos, Valfredo de Almeida Santos Júnior, Júlia Demuner Pimentel, Gabriel Lusi Fernandes Carregã, Cínthia Baú Betim Cazarin,

Tópico(s)

Connective Tissue Growth Factor Research

Resumo

Collagen is one of the main components of the extracellular matrix of the dermis and articular cartilage and influences the body's mechanical, organizational, and tissue formation properties. Produced from food industry by-products, it is considered a nutraceutical product widely used as an ingredient or supplement in food, pharmaceutical, and cosmetic industries. This study aimed to conduct a literature review on the scientific evidence regarding the beneficial effects of collagen consumption in the treatment of skin and orthopedic diseases. Literature data have shown that hydrolyzed collagen supplementation promotes skin changes, such as decreased wrinkle formation; increased skin elasticity; increased hydration; increased collagen content, density, and synthesis, which are factors closely associated with aging-related skin damage. Regarding orthopedic changes, collagen supplementation increases bone strength, density, and mass; improves joint stiffness/mobility, and functionality; and reduces pain. These aspects are associated with bone loss due to aging and damage caused by strenuous physical activity. Thus, this review addresses the economic and health potential of this source of amino acids and bioactive peptides extracted from food industry by-products.

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