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Prevention of invasive ventilation (PRiVENT)—a prospective, mixed-methods interventional, multicentre study with a parallel comparison group: study protocol

2023; BioMed Central; Volume: 23; Issue: 1 Linguagem: Inglês

10.1186/s12913-023-09283-0

1472-6963

Júlia Michels, Jan Meis, Noemi Sturm, Florian Bornitz, Selina von Schumann, Aline Weis, Benjamin Neetz, Martina Bentner, Johanna Forstner, Nicola Litke, Michel Wensing, Stella Erdmann, Thomas Grobe, Timm Frerk, Axel Kempa, Claus Neurohr, Armin Schneider, Michael Müller, Felix J.F. Herth, Joachim Szécsényi, Franziska Trudzinski, Franziska Trudzinski, G. Iberl, B Müller, Elena Biehler, Thomas Fleischhhauer, Gerhard Fuchs, Markus Qreini, Janina Schubert-Haack, Anja Klingenberg, Alex Kempa, Biljana Joves, Andreas Rheinhold, Alessandro Ghiani, Nina Lutz, Swenja Walcher, Κωνσταντίνος Τσίτουρας, Joanna Paderewska, Selina Briese, Christoph Andritschky, Patrick Gehrig, Joachim Sugg, Susanne Hirschmann, Simone Britsch, Christa Straub, Claude Jabbour, Michael Hahn, Joerg Krebs, Peter-Tobias Graf, Petra Denzer, Mascha O. Fiedler, Miriane Bomeken, Sebastian Stier, Tom Terboven, Uta Merle, Jens Regula, Jens Müller, Ute Oltmanns, Marcus Hennersdorf, Neslihan Satir, Mathias M. Borst, Brigitte Mayèr, Wolfgang Reikow, Markus Kredel, Konstantin Frey, Holger Wolff, Florian Seidlitz, Stefanie Bientzle, Boris Nohé, Sebastian Allgäuer, Alexej Schöpp, Christoph Schlegel, Imke Hübner, Andrezj Kuzniar, Helene Häberle, Reimer Rießen, Benjamin Schempf, Ingo Rebenschütz, Andreas Straub, Marc Kollum, Markus Winter, Paul Hartveg, Andreas Junginger, Helmut Beck, Mathias Vogel,

Sepsis Diagnosis and Treatment

Abstract Background Invasive mechanical ventilation (IMV) is a standard therapy for intensive care patients with respiratory failure. With increasing population age and multimorbidity, the number of patients who cannot be weaned from IMV increases, resulting in impaired quality of life and high costs. In addition, human resources are tied up in the care of these patients. Methods The PRiVENT intervention is a prospective, mixed-methods interventional, multicentre study with a parallel comparison group selected from insurance claims data of the health insurer Allgemeine Ortskrankenkasse Baden-Württemberg (AOK-BW) conducted in Baden-Württemberg, Germany, over 24 months. Four weaning centres supervise 40 intensive care units (ICUs), that are responsible for patient recruitment. The primary outcome, successful weaning from IMV, will be evaluated using a mixed logistic regression model. Secondary outcomes will be evaluated using mixed regression models. Discussion The overall objective of the PRiVENT project is the evaluation of strategies to prevent long-term IMV. Additional objectives aim to improve weaning expertise in and cooperation with the adjacent Intensive Care Units. Trial registration This study is registered at ClinicalTrials.gov (NCT05260853).