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The Omicron Lineages BA.1 and BA.2 (Betacoronavirus SARS-CoV-2) Have Repeatedly Entered Brazil through a Single Dispersal Hub

2023; Multidisciplinary Digital Publishing Institute; Volume: 15; Issue: 4 Linguagem: Inglês

10.3390/v15040888

1999-4915

Alessandra P. Lamarca, Ueric José Borges de Souza, Filipe Romero Rebello Moreira, Luiz Gonzaga Paula de Almeida, Mariane Talon de Menezes, Adrieli Barboza de Souza, Alessandro Clayton de Souza Ferreira, Alexandra Lehmkuhl Gerber, Aline Brito de Lima, Ana Paula de Campos Guimarães, Andréa Cony Cavalcanti, Aryel Beatriz Paz e Silva, Bruna Israel Lima, Cirley Lobato, Cristiane Gomes da Silva, C P Mendonça, Daniel Costa Queiroz, Danielle Alves Gomes Zauli, Diego Menezes, Fábio Sossai Possebon, Franciano Dias Pereira Cardoso, Frederico Scott Varella Malta, Isabela Braga-Paz, Joice do Prado Silva, Jorge G. Ferreira, Jucimária Dantas Galvão, Leandro Magalhães de Souza, Leonardo Ferreira, Lia Gonçalves Possuelo, Liliane Cavalcante, Luige Biciati Alvim, Luiz Fellype Alves de Souza, Luíza Campos Guerra de Araújo e Santos, Rillery Calixto Dias, Rutilene Barbosa Souza, Thaís Regina y Castro, Andréia Rosane de Moura Valim, Fabrício Souza Campos, João Pessoa Araújo Júnior, Priscila de Arruda Trindade, Renato Santana Aguiar, Robson Michael Delai, Ana Tereza Ribeiro de Vasconcelos,

Bacillus and Francisella bacterial research

Brazil currently ranks second in absolute deaths by COVID-19, even though most of its population has completed the vaccination protocol. With the introduction of Omicron in late 2021, the number of COVID-19 cases soared once again in the country. We investigated in this work how lineages BA.1 and BA.2 entered and spread in the country by sequencing 2173 new SARS-CoV-2 genomes collected between October 2021 and April 2022 and analyzing them in addition to more than 18,000 publicly available sequences with phylodynamic methods. We registered that Omicron was present in Brazil as early as 16 November 2021 and by January 2022 was already more than 99% of samples. More importantly, we detected that Omicron has been mostly imported through the state of São Paulo, which in turn dispersed the lineages to other states and regions of Brazil. This knowledge can be used to implement more efficient non-pharmaceutical interventions against the introduction of new SARS-CoV variants focused on surveillance of airports and ground transportation.