Metoclopramide: Pharmacology and Clinical Application
1983; American College of Physicians; Volume: 98; Issue: 1 Linguagem: Inglês
10.7326/0003-4819-98-1-86
ISSN1539-3704
Autores Tópico(s)Nausea and vomiting management
ResumoReview1 January 1983Metoclopramide: Pharmacology and Clinical ApplicationRIYAD ALBIBI, M.D., RICHARD W. McCALLUM, M.D.RIYAD ALBIBI, M.D., RICHARD W. McCALLUM, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-1-86 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMetoclopramide antagonizes the effect of dopamine in the central nervous system and other organ systems. Metoclopramide's effect on the medullary chemoreceptor trigger zone makes it useful as a routine anti-emetic and in preventing vomiting induced by antineoplastic drugs, particularly cisplatin. Metoclopramide's gastrointestinal smooth muscle stimulatory effects are related to its ability to antagonize the inhibitory neurotransmitter, dopamine; to augment acetylcholine release and sensitize the muscarinic receptors of the gastrointestinal smooth muscle; and to coordinate gastric-pyloric-small intestinal motor function. The indications for which metoclopramide is approved in the United States are reviewed. Adverse effects, which may occur in up to 20%...References1. BESANCOULAVILLETHOMINET JCM. Le metoclopramide et ses homoloques: introduction a leur etude biologique. C R Acad Sci (Paris). 1964;258:4384-6. MedlineGoogle Scholar2. PINDERBROGDENSAWYERSPEIGHTAVERY RRPTG. Metoclopramide: a review of its pharmacological properties and clinical use. Drugs. 1976;12:81-131. CrossrefMedlineGoogle Scholar3. OKWUASABAHAMILTON FJ. The effect of metoclopramide on intestinal muscle responses and the peristaltic reflex in vitro. Can J Physiol Pharmacol. 1976;54:393-404. CrossrefMedlineGoogle Scholar4. BIRTLEYBAINES RM. The effects of metoclopramide on some isolated intestinal preparations. Postgrad Med J. 1973;49(suppl 4):13-8. Google Scholar5. MCCALLUMBERKOWITZCALLACHAN RDC. Comparative effects of metoclopramide and bethanechol on gastric emptying in gastroesophageal reflux patients. Gastroenterology. (In press). Google Scholar6. JACOBYBRODIE HD. Gastrointestinal actions of metoclopramide: an experimental study. Gastroenterology. 1967;52:676-84. CrossrefMedlineGoogle Scholar7. CONNELLGEORGE AJ. Effect of metoclopramide on gastric function in man. Gut. 1969;10:678-80. CrossrefMedlineGoogle Scholar8. LINARESLEMBERGDRAGSTEDT CAL. Gastric peristalsis as stimulus of acid section in man. Arch Surg. 1969;99:459-61. CrossrefMedlineGoogle Scholar9. MCCALLUMKLINECURRYSTURDEVANT RMNR. Comparative effects of metoclopramide and bethanechol on lower esophageal sphincter pressure in reflux patients. Gastroenterology. 1975;68:1114-8. CrossrefMedlineGoogle Scholar10. STADAASAUNE JS. The effect of metoclopramide (Primperan) on gastric motility before and after vagotomy in man. Scand J Gastroenterol. 1971;6:17-21. CrossrefMedlineGoogle Scholar11. EISNER M. Gastrointestinal effects of metoclopramide in man: in vitro experiments with human smooth muscle preparations. Br Med J. 1968;4:679-80. CrossrefMedlineGoogle Scholar12. KOWALEWSKIKALODEJ KA. Effect of metoclopramide on myoelectrical and mechanical activity of the isolated canine stomach perfused extracorporeally. Pharmacology. 1975;13:549-62. CrossrefMedlineGoogle Scholar13. BEANIBIANCHICREMA LCC. Effects of metoclopramide on isolated guinea-pig colon: 1. Peripheral sensitization to acetylcholine. Eur J Pharmacol. 1970;12:320-31. CrossrefMedlineGoogle Scholar14. FOXBEHAR SJ. Pathogenesis of diabetic gastroparesis: a pharmacologic study. Gastroenterology. 1980;78:757-63. CrossrefMedlineGoogle Scholar15. SCHULZE-DELRIEU K Metoclopramide. Gastroenterology. 1979;77: 768-79. CrossrefMedlineGoogle Scholar16. HAYMAN AW. Effect of metoclopramide on guinea pig stomach: critical dependence on intrinsic stores of acetylcholine. Gastroenterology. 1979;76:492-6. CrossrefMedlineGoogle Scholar17. JOHNSON A. Gastroduodenal motility and synchronization. Postgrad Med J 1973;49(suppl4):29-33. MedlineGoogle Scholar18. HAY A. Pharmacological analysis of the effects of metoclopramide on the guinea pig isolated stomach. Gastroenterology. 1977;72:864-9. CrossrefMedlineGoogle Scholar19. THORNER M. Dopamine is an important neurotransmitter in the autonomic nervous system. Lancet. 1975;1:662-5. CrossrefMedlineGoogle Scholar20. JENNERMARSDEN PC. The substituted benzamides—a novel class of dopamine antagonists. Life Sci. 1979;25:479-85. CrossrefMedlineGoogle Scholar21. LAFRANCHIMARZIOCORTINICTRENTOLABO GLCLG. Effect of dopamine in gastric motility in man: evidence for specific receptors. In: DUTHIE HL, ed. Gastrointestinal Motility in Health and Disease. Lancaster, England: MTP Publishers; 1977:161-72. Google Scholar22. BAUMANSTURDEVANTMCCALLUM HRR. L-dopa inhibits metoclopramide stimulation of the lower esophageal sphincter in man. Am J Dig Dis. 1979; 24:289-95. Google Scholar23. BERKOWITZMCCALLUM DR. Interaction of levodopa and metoclopromide on gastric emptying. Clin Pharmacol Ther. 1980; 27:414-20. CrossrefMedlineGoogle Scholar24. RAMSBOTTOMHUNT NJ. Studies of the effect of metoclopramide and apomorphine on gastric emptying and secretion in man. Gut. 1970; 11:989-93. CrossrefMedlineGoogle Scholar25. JOHNSON A. The action of metoclopramide on human gastroduodenal motility. Gut. 1971; 12:421-6. CrossrefMedlineGoogle Scholar26. PEARSONEDWARDTATEGILKESSAXTONHOWLAND MDARHC. Comparison of the effects of oral and intravenous metoclopramide on the small bowel. Postgrad Med J. 1973;49(suppl 4):47-50. Google Scholar27. MALAGELADARESSMAZZOTTAGO JWLV. Gastric motor abnormalities in diabetic and postvagotomy gastroparesis—effect of metoclopramide and bethanechol. Gastroenterology. 1980;78:286-93. CrossrefMedlineGoogle Scholar28. VALENZUELA J. Dopamine as a possible neurotransmitter in gastric relaxation. Gastroenterology. 1976;71:1019-22. CrossrefMedlineGoogle Scholar29. METZGERCANOSTURDEVANT WRR. Effect of metoclopramide in chronic gastric retention after gastric surgery. Gastroenterology. 1976;71:30-2. CrossrefMedlineGoogle Scholar30. COHENDIMARINO SA. Mechanism of action of metoclopramide on opossum lower esophageal sphincter muscle. Gastroenterology. 1976;71:996-8. CrossrefMedlineGoogle Scholar31. PROCTORCHREMOSEVANSWASSERMAN JAEA. An apomorphine-induced vomiting model for antiemetic studies in man. J Clin Pharmacol. 1978;18:95-9. CrossrefMedlineGoogle Scholar32. KOTTKESPRINGERPOHLOUDEK-FABINI DMR. Untersuchungen zur Stabilitat von Metoclopramidlosungen in Glas- und Plastbehaltern Pharmazie. 1978;33:198-210. Google Scholar33. BAKKESEGURA OJ. The absorption and elimination of metoclopramide in three animal species. J Pharmacol. 1976;28:32-9. CrossrefGoogle Scholar34. BATEMANGOKALDODDBLAIN DRRP. The pharmacokinesthetics of single doses of metoclopramide in renal failure. Eur J Clin Pharmacol. 1981;19:437-41. CrossrefMedlineGoogle Scholar35. COHENMORRISSCHOENDIMARINO SDHA. The effect of oral and intravenous metoclopramide on human lower esophageal sphincter pressure. Gastroenterology. 1976;70:484-7. CrossrefMedlineGoogle Scholar36. WALLINBOESBYMADSEN LST. Effect of metoclopramide on oesophageal peristalsis and gastrooesophageal sphincter pressure. Scand J Gastroenterol. 1979;14:923-7. MedlineGoogle Scholar37. STANCIUBENNETT CJ. Metoclopramide in gastrooesophageal reflux. Gut. 1973;14:275-9. CrossrefMedlineGoogle Scholar38. WINNANAVELLACALLACHANMCCALLUM JJCR. Double-blind trial of metoclopramide versus placebo-antacid in symptomatic gastroesophageal reflux [Abstract]. Gastroenterology. 1980;78:1292. Google Scholar39. MCCALLUMBERKOWITZLERNER RDE. Gastric emptying in patients with gastroesophageal reflux. Gastroenterology. 1981;80:285-91. CrossrefMedlineGoogle Scholar40. BEHARRAMSBY JG. Gastric emptying and antral motility in reflux esophagitis: effect of oral metoclopramide. Gastroenterology. 1978;74:253-6. CrossrefMedlineGoogle Scholar41. MCCALLUMMENSHLANGE RRR. Definition of the gastric emptying abnormality present in gastroesophageal reflux patients. In: WEINBECK M, ed. Motility of the Digestive Tract. New York: Raven Press; 1982:355-62. Google Scholar42. HILLEMEIERLANGEMCCALLUMSEASHOREGRYBOSKI ARRJJ. Delayed gastric emptying in infants with gastroesophageal reflux. J Pediatr. 1981;98:190-3. CrossrefMedlineGoogle Scholar43. BEHARBIANCANI JP. Effect of oral metoclopramide on gastroesophageal reflux in the post-cibal state. Gastroenterology. 1976;70:331-5. CrossrefMedlineGoogle Scholar44. MCCALLUMIPPOLITICOONEYSTURDEVANT RACR. A controlled trial of metoclopramide in symptomatic gastroesophageal reflux. TV Engl J Med. 1977;296:354-7. CrossrefMedlineGoogle Scholar45. BRIGHT-ASAREEL-BASSOUSSI PM. Cimetidine, metoclopramide or placebo in the treatment of symptomatic gastroesophageal reflux. J Clin Gastroenterol. 1980;2:149-56. CrossrefMedlineGoogle Scholar46. PERKELMOOREHERSCHDAVIDSON MCTE. Metoclopramide therapy in patients with delayed gastric emptying—a randomized, double-blind study. Dig Dis Sci. 1979;24:662-6. CrossrefMedlineGoogle Scholar47. JOHNSON A. The action of metoclopramide on the canine stomach, duodenum, and gall-bladder [Abstract]. Br JSurg. 1969;56:696. MedlineGoogle Scholar48. KASSANDER P. Asymptomatic gastric retention in diabetes (gastroparesis diabeticorum). Ann Intern Med. 1958;48:797-812. LinkGoogle Scholar49. FELDMANCORBETTRAMSEYWALSHRICHARDSON MDEJC. Abnormal gastric function in longstanding insulin-dependent diabetic patients. Gastroenterology. 1979;77:1247-54. CrossrefGoogle Scholar50. BROWNLEEKROOPF MS. Metoclopramide for gastroparesis diabeticorum [Letter]. N Engl J Med. 1974;291:1257-8. CrossrefMedlineGoogle Scholar51. LONGSTRETHMALAGELADAKELLY GJK. Metoclopramide stimulation of gastric motility and emptying in diabetic gastroparesis [Letter]. Ann Intern Med. 1977;86:195-6. LinkGoogle Scholar52. HARTONGMOOREBOOTH WJJ. Metoclopramide in diabetic gastroparesis [Letter]. Ann Intern Med. 1977;86:826. LinkGoogle Scholar53. CAMPBELLHEADINGTOTHILLBUISTEWINGCLARK IRPTDB. Gastric emptying in diabetic autonomic neuropathy. Gut. 1977;18:462-7. CrossrefMedlineGoogle Scholar54. SOERGELPALMERLOOWOOD KDFC. Abnormal gastric emptying in diabetics and the effect of metoclopramide [Abstract]. Gastroenterology. 1980;78:1265. Google Scholar55. SALTZMANMEYERCALLACHANMCCALLUM MCCR. Effect of metoclopramide on chronic gastric stasis in diabetic and post-gastric surgery patients [Abstract]. Gastroenterology. 1981;80:1268. Google Scholar56. MCCLELLANDHORTON RJ. Relief of acute, persistent postvagotomy atony by metoclopramide. Ann Surg. 1978;188:439-45. MedlineGoogle Scholar57. STADAASAUNE JS. The effect of metoclopramide (Primperan) on gastric motility before and after vagotomy in man. Scand J Gastroenterol 1971;6:17-21. CrossrefMedlineGoogle Scholar58. STADAASAUNE JS. Clinical trial of metoclopramide in postvagotomy gastric stasis. Arch Surg. 1972;104:684-5. CrossrefMedlineGoogle Scholar59. HANCOCKBOWEN-JONESDIXONDYMOCKCOWLEY BERID. The effect of metoclopramide on gastric emptying of solid meals. Gut. 1974;15:462-7. CrossrefMedlineGoogle Scholar60. METZGERCANOSTURDEVANT WRR. Effect of metoclopramide in chronic gastric retention after gastric surgery [Abstract]. Gastroenterology. 1975;68:954. Google Scholar61. DAVIDSONHERSHHAUNBRANK ETCW. Use of metoclopramide in patients with delayed gastric emptying following gastric surgery. Am Surg. 1977;43:40. MedlineGoogle Scholar62. MCCALLUMSALTZMANMEYER RMC. Effect of metoclopramide in chronic gastric retention after gastric surgery [Abstract]. Clin Res. 1980;28:765A. Google Scholar63. FRANKLANGEMCCALLUM ERR. Abnormal gastric emptying in patients with atrophic gastritis with or without pernicious anemia [Abstract ]. Gastroenterology. 1981 ;80:1151. Google Scholar64. YOULEECHEYMENGUY CKWR. Electrogastrographic study of patients with unexplained nausea, bloating and vomiting. Gastroenterology. 1980;79:311-4. CrossrefMedlineGoogle Scholar65. TELANDERMORGANKREULERSCHMALZKELLYSZURSZEWSKI RKDPKJ. Human gastric atony with tachygastria and gastric retention. Gastroenterology. 1978;75:497-501. CrossrefMedlineGoogle Scholar66. SANDERSMENGUYCHEY KRW. One explanation for human antral tachygastria [Abstract]. Gastroenterology. 1979;76:1234. Google Scholar67. DRAGSTEDT L. A concept of the etiology of gastric and duodenal ulcer. Am J Roentgen. 1956;75:219-29. Google Scholar68. MANGOLD R. Combined gastric and duodenal ulceration. A survey of 157 cases. Br Med J. 1958;2:1193-7. CrossrefMedlineGoogle Scholar69. JOHNSON H. The special significance of concomitant gastric and duodenal ulcers. Lancet. 1955;1:266-70. CrossrefGoogle Scholar70. GARRETTSUMMERSKILLCODE JWC. Antral motility in patients with gastric ulcer. Am J Dig Dis. 1966;11:780-9. CrossrefMedlineGoogle Scholar71. MILLERMALAGELADALONGSTRETHGO LJGV. Dysfunction of the stomach with gastric ulceration. Dig Dis Sci. 1980;25:857-64. CrossrefMedlineGoogle Scholar72. MECKLENBURGLORIAUXTHOMSONANDERSENLIPSETT RDRAM. Hypothalamic dysfunction in patients with anorexia nervosa. Medicine. 1974;53:147-59. CrossrefMedlineGoogle Scholar73. LUCAS A. Toward understanding of anorexia nervosa as a disease entity. Mayo Clinic Proc. 1981;56:254-64. MedlineGoogle Scholar74. BARRYKLAWANS VH. On the role of dopamine in the pathophysiology of anorexia nervosa. J Neural Transm. 1976;38:107-22. CrossrefMedlineGoogle Scholar75. GRILLGREENFELDGLASSLANGEMCCALLUM BDERR. Definition of a gastric emptying abnormality in patients with anorexia nervosa [Abstract]. Clin Res. 1982;30:283A. Google Scholar76. SALEHLEBWOHL JT. Metoclopramide-induced gastric emptying in patients with anorexia nervosa. Am J Gastroenterol. 1980;74:127-32. MedlineGoogle Scholar77. LIPTONKNAUER AC. Pseudo-obstruction of the bowel: therapeutic trial of metoclopramide. Am J Dig Dis. 1977;22:263-5. CrossrefMedlineGoogle Scholar78. SCHUFFLERROHRMANNCHAFFEEBRANDDELANEYYOUNG MCRDJJ. Chronic intestinal pseudo-obstruction (review). Medicine. 1981;60:173-96. CrossrefMedlineGoogle Scholar79. JONES C. Metoclopramide in the treatment of nausea: a double-blind trial. New Zealand Med J. 1968;68:388-93. MedlineGoogle Scholar80. SINGHLEAN MT. The use of metoclopramide in hyperemesis gravidarum. Proceedings of the Obstetrical and Gynecological Society, Singapore. 1970;1:43-9. Google Scholar81. KAHNELIASMASON TEG. A single dose of metoclopramide in the control of vomiting from cis-dichlorodiammineplatinum (II) in man [Letter]. Cancer Treat Rep. 1978;62:1106-7. MedlineGoogle Scholar82. GRALLASQUILLANTESTEELEKELSENYOUNG RANDC. Phase I intravenous trial of the antiemetic metoclopramide in patients receiving cis-platinum (DDP) [Abstract]. Proc Am Soc Clin Oncol. 1980;21:350. Google Scholar83. GRALLAITRIPISKO RLS. Antiemetic efficacy of highdose metoclopramide: randomized trials with placebo and prochlorperazine in patients with chemotherapy-induced nausea and vomiting. N Engl J Med. 1981 ;305:905-9. CrossrefMedlineGoogle Scholar84. MOSHAL M. A rapid jejunal biopsy technique aided by metoclopramide: a double-blind trial with 50 patients. Postgrad Med J. 1973;49(suppl4): 87-9. Google Scholar85. CHRISTIEAMENT DM. A double blind crossover study of metoclopramide versus placebo for facilitating passage of multipurpose biopsy tube. Gastroenterology. 1976;71:726-8. CrossrefMedlineGoogle Scholar86. JAMESHUME WR. Action of metoclopramide on gastric emptying and small bowel transit time. Gut. 1968;9:203-5. CrossrefMedlineGoogle Scholar87. DAVIDSONHERSHBRINNERBARNETTBOYLE ETRSL. The effects of metoclopramide on postoperative ileus: a randomized double-blind study. Ann Surg. 1979;190:27-30. CrossrefMedlineGoogle Scholar88. BREIVIKLIND HB. Anti-emetic and propulsive peristaltic properties of metoclopramide. Br J Anesth. 1971;43:400-3. CrossrefMedlineGoogle Scholar89. MCCALLUMSOWERSHERSHMANSTURDEVANT RJJR. Metoclopramide stimulates prolactin secretion in man. J Clin Endocrinol Metab. 1976;42:1148-52. CrossrefMedlineGoogle Scholar90. SOWERSMCCALLUMHERSHMANCARLSONSTURDEVANTMEYER JRJHRN. Comparison of metoclopramide with other dynamic tests of prolactin secretion. J Clin Endocrinol Metab. 1976;43:679-81. CrossrefMedlineGoogle Scholar91. COHENHAYBEASTALLTHOMSON HIGJ. Metoclopramide induced growth hormone release in hypogonadal males. Clin Endocrinol. 1979;11:95-7. CrossrefMedlineGoogle Scholar92. NOTHMCCALLUMCONTINOHAVLICK RRCJ. Tonic dopaminergic suppression of plasma aldosterone. J Clin Endocrinol Metab. 1980;51:64-9. CrossrefMedlineGoogle Scholar93. SOWERSSHARPMCCALLUM JBR. Effect of domperidone, an extracerebral inhibitor of dopamine receptors, on thyrotropin, prolactin, renin, aldosterone and 18-hydroxycorticosterone in man. J Clin Endocrinol Metab. 1982;54:869-71. CrossrefMedlineGoogle Scholar94. KUCHELBUUGUTKOWSKAGENEST ONJJ. Treatment of severe orthostatic hypotension by metoclopramide. Ann Intern Med. 1980;93:841-3. LinkGoogle Scholar95. FRIMODT-MØLLERMORTENSEN CS. Treatment of diabetic cystopathy. Ann Intern Med. 1980;92:327-8. LinkGoogle Scholar96. ROBINSON O. Metoclopramide—-side effects and safety. Postgrad Med J 1973;49(suppl 4):77-80. MedlineGoogle Scholar97. CASTEELS-VAN DAELEJAEKENVAN DER SCHUERENZIMMERMANVANDENBON MJPAP. Dystonie reactions in children caused by metoclopramide. Arch Dis Child. 1970;45:130-3. CrossrefMedlineGoogle Scholar98. MEARRICKWADEBIRKELTMORRIS PDDJ. Metoclopramide, gastric emptying and L-dopa absorption. Aust N Z J Med. 1974;4:144-8. CrossrefMedlineGoogle Scholar99. MANNINENAPAJALHTISIMMENREISSEL VAHP. Effect of propantheline and metoclopramide on absorption of digoxin [Letter]. Lancet. 1973;1:1118-9. CrossrefMedlineGoogle Scholar100. AGABITI-ROSIEALICANDRICOREA ECL. Hypertensive crisis in patients with pheochromocytoma given metoclopramide [Letter]. Lancet. 1977; 1:600. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New Haven, ConnecticutFrom the Department of Internal Medicine, Section of Gastroenterology, Yale University School of Medicine; New Haven, Connecticut. 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A prospective, randomized, double blind studyPathophysiology and Management of Diabetic GastropathyGastric Motility, Gastroparesis, and Gastric StimulationAproximación psicológica a la hiperemesis gravídicaRecent advances in equine abdominal surgeryPreventing prolonged post-operative ileus in gastric cancer patients undergoing gastrectomy and intra-peritoneal chemotherapyThe Treatment of Diabetic Gastroparesis With Botulinum Toxin Injection of the PylorusPharmacologic management and treatment of gastroesophageal reflux diseaseGastric Motility DisordersMedical management of the pregnant patient with inflammatory bowel diseaseTreatment of gastroparesisErythromycin in the Short- and Long-term Control of Dyspepsia Symptoms in Patients with GastroparesisGastrointestinal ComplicationsModifiers of gastrointestinal motility of cattleManagement of Gastroesophageal Reflux DiseaseDiagnosis and treatment of neuromuscular disorders of the stomachDiagnosis and treatment of chronic gastroparesis and chronic intestinal pseudo-obstructionFAILURE TO THRIVE RELATED TO METOCLOPRAMIDE THERAPYAutonomic dysfunctionChronic Metoclopramide Therapy for Diabetic GastroparesisResponse of Diamond-Blackfan anemia to metoclopramide: evidence for a role for prolactin in erythropoiesisNew insights into the treatment of gastroesophageal reflux diseaseMetoclopramide-Induced Supersensitivity PsychosisDomperidone is more effective than cisapride in children with diabetic gastroparesisThe Gastroprokinetic and Antiemetic Drug Metoclopramide Is a Substrate and Inhibitor of Cytochrome P450 2D6Hyperglycemia impairs antro-pyloric coordination and delays gastric emptying in conscious ratsEvaluation and Management of a Child With VomitingPharmacoeconomic issues of the treatment of gastroesophageal reflux diseaseThe cardiovascular effects of metoclopramide in multiple system atrophy and pure autonomic failureComparison of Gastrointestinal Tolerance to Two Enteral Feeding Protocols in Critically III Patients: A Prospective, Randomized Controlled TrialAGA technical review on nausea and vomitingPreparation and in vivo evaluation of parenteral metoclopramide-loaded poly(alkylcyanoacrylate) nanospheres in ratsPharmacotherapy of gastroparesisComparative effects of levosulpiride and cisapride on gastric emptying and symptoms in patients with functional dyspepsia and gastroparesisGrundlagen der gastrointestinalen MotilitätThe role of prophylactic anti-emetic therapy in emergency department patients receiving intravenous morphine for musculoskeletal traumaEsophageal pharmacology and treatment of primary motility disordersThe Aging EsophagusProkinetic agents in the surgical patientComparative Efficacy and Safety of Ondansetron, Droperidol, and Metoclopramide for Preventing Postoperative Nausea and VomitingComparative Efficacy and Safety of Ondansetron, Droperidol, and Metoclopramide for Preventing Postoperative Nausea and VomitingNeglect and Abuse Associated with Undernutrition in Long-Term Care in North America: Causes and SolutionsA Double-Blind Multicenter Comparison of Domperidone and Metoclopramide in The Treatment of Diabetic Patients With Symptoms of Gastroparesis Fig. 1Neuroleptic Malignant Syndrome Associated with MetoclopramideDomperidone: A Peripherally Acting Dopamine 2 -Receptor AntagonistNitrogen-containing heteroalicycles with serotonin receptor binding affinity: Development of gastroprokinetic and antiemetic agentsDelta-9-tetrahydrocannabinol delays the gastric emptying of solid food in humans: a double-blind, randomized studyThe clinical significance of acquired jejunoileal diverticulaDetermination of Metoclopramide in Serum by HPLC Assay and Its Application to Pharmacokinetic Study in RatOptions in the Treatment of Chemotherapy-Induced EmesisThe Law and Malnutrition: Strange Bedfel
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