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A spotlight on the interplay of signaling pathways and the role of miRNAs in osteosarcoma pathogenesis and therapeutic resistance

2023; Elsevier BV; Volume: 245; Linguagem: Inglês

10.1016/j.prp.2023.154442

1618-0631

Ahmed S. Doghish, Maghawry Hegazy, Ahmed Ismail, Hesham A. El-Mahdy, Elsayed G.E. Elsakka, Samy Y. Elkhawaga, Mohamed A. Elkady, Amr Mohamed Yehia, Nourhan M. Abdelmaksoud, Mahmoud Mohamed Mokhtar,

Circular RNAs in diseases

Osteosarcoma (OS) is one of the most common bone cancers that constantly affects children, teenagers, and young adults. Numerous epigenetic elements, such as miRNAs, have been shown to influence OS features like progression, initiation, angiogenesis, and treatment resistance. The expression of numerous genes implicated in OS pathogenesis might be regulated by miRNAs. This effect is ascribed to miRNAs' roles in the invasion, angiogenesis, metastasis, proliferation, cell cycle, and apoptosis. Important OS-related mechanistic networks like the WNT/b-catenin signaling, PTEN/AKT/mTOR axis, and KRAS mutations are also affected by miRNAs. In addition to pathophysiology, miRNAs may influence how the OS reacts to therapies like radiotherapy and chemotherapy. With a focus on how miRNAs affect OS signaling pathways, this review seeks to show how miRNAs and OS are related.