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Polysaccharide-Rich Extract of Caesalpinia ferrea Stem Barks Modulates Inflammatory and Proliferative Phases Enhancing Diabetic Cutaneous Wound

2023; Volume: 18; Issue: 3 Linguagem: Inglês

10.3923/jpt.2023.112.119

2152-100X

Ana Maria Sampaio Assreuy, Iásly Costa Lima, Laryssa F. Mendonça, Lívia de Paulo Pereira, Stephanie B. Oliveira, Ana N.N. Alves, Maria Gonçalves Pereira, Mario L. Mota,

Diabetic Foot Ulcer Assessment and Management

Background and Objective: Diabetes decreases glucose metabolism, leading to hyperglycemia and delayed wound healing.Caesalpinia ferrea or Libidibia ferrea (Fabaceae), popularly known as "pau ferro", "jucá" or "jucaína", is widely used in folk medicine for inflammatory conditions.Caesalpinia ferrea barks are used in the form of tea and portions to clean injuries and treat wounds and its stem barks infusion to treat enterocolitis, asthma, bruises, chronic cough and wounds.This study aimed to investigate the effect of the polysaccharide-rich extract of C. ferrea stem barks (PE-Cf) in the model of excisional cutaneous wounds in diabetic rats.Materials and Methods: The PE-Cf was obtained by a combination of NaOH extraction and ethanol precipitation.The analysis of the NMR spectra of PE-Cf revealed a central core composed mostly of 5-linked "-Araf and minority constituents such as "-Rhap and "-GalAp.For diabetes induction, rats received alloxan (45 mg kgG 1 ) by the intravenous route for pancreatic $ cell destruction.One month later, rats that had blood glucose >200 mg dLG 1 were selected to be tested in the model of the excisional cutaneous wound.PE-Cf (0.025-0.1%) was topically applied to the wounds twice a day for 14 days for evaluation of hyper-nociception (digital analgesimetry), clinical signs (macroscopy) and histopathology/ histomorphometry.Results: 0.1% PE-Cf reduced wound area (2-7 th day), hyper-nociception (5-10 th day), crust detachment (5-7 th day), scar tissue formation (10 th day), leukocyte infiltration (5-7 th day) and increased fibroblast/myofibroblast (5 th and 7 th day).Conclusion: The PE-Cf accelerates the healing process of diabetic rats, acting both in the inflammatory and proliferative phases.This study validates the popular use of C. ferrea barks in the inflammatory process and suggests PE-Cf as an alternative therapy to healing diabetic wounds.