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Inflammatory Response and Activation of Coagulation after COVID-19 Infection

2023; Multidisciplinary Digital Publishing Institute; Volume: 15; Issue: 4 Linguagem: Inglês

10.3390/v15040938

1999-4915

Anna Glória Fonseca Teodoro, Wellington Francisco Rodrigues, Thaís Soares Farnesi-de-Assunção, Anna Victória Bernardes e Borges, Malú Mateus Santos Obata, José Rodrigues do Carmo Neto, Djalma A. Alves da Silva, Leonardo Eurípedes Andrade-Silva, Chamberttan Souza Desidério, Juliana Cristina Costa-Madeira, Rafaela Miranda Barbosa, Andrezza Cristina Cancian Hortolani, Loren Queli Pereira, Fernanda Bernadelli De Vito, Sarah Cristina Sato Vaz Tanaka, Fernanda Rodrígues Helmo, Marcela Rezende Lemes, Laís Milagres Barbosa, Rafael Obata Trevisan, Fabiano Vilela Mundim, Ana Carolina de Morais Oliveira-Scussel, Paulo Roberto Resende, Ivan Borges Monteiro, Yulsef M. Ferreira, Guilherme H. Machado, Kennio Ferreira‐Paim, Hélio Moraes‐Souza, Carlo José Freire Oliveira, Virmondes Rodrigues, Marcos Silva,

Long-Term Effects of COVID-19

SARS-CoV-2 (COVID-19) infection is responsible for causing a disease with a wide spectrum of clinical presentations. Predisposition to thromboembolic disease due to excessive inflammation is also attributed to the disease. The objective of this study was to characterize the clinical and laboratory aspects of hospitalized patients, in addition to studying the pattern of serum cytokines, and associate them with the occurrence of thromboembolic events. Methodology: A retrospective cohort study with 97 COVID-19 patients hospitalized from April to August 2020 in the Triângulo Mineiro macro-region was carried out. A review of medical records was conducted to evaluate the clinical and laboratory aspects and the frequency of thrombosis, as well as the measurement of cytokines, in the groups that presented or did not present a thrombotic event. Results: There were seven confirmed cases of thrombotic occurrence in the cohort. A reduction in the time of prothrombin activity was observed in the group with thrombosis. Further, 27.8% of all patients had thrombocytopenia. In the group that had thrombotic events, the levels of IL1b, IL-10, and IL2 were higher (p < 0.05). Conclusions: In the studied sample, there was an increase in the inflammatory response in patients with thrombotic events, confirmed by the increase in cytokines. Furthermore, in this cohort, a link was observed between the IL-10 percentage and an increased chance of a thrombotic event.