98. Cellular Senescence in Late-Life Depression
2023; Elsevier BV; Volume: 93; Issue: 9 Linguagem: Inglês
10.1016/j.biopsych.2023.02.338
ISSN1873-2402
AutoresJohanna Seitz‐Holland, Benoit H. Mulsant, Charles F. Reynolds, Daniel M. Blumberger, Jordan F. Karp, Meryl A. Butters, Ana Paula Mendes‐Silva, Érica Leandro Marciano Vieira, George C. Tseng, Eric J. Lenze, Breno S. Diniz,
Tópico(s)Genetics, Aging, and Longevity in Model Organisms
ResumoLate-life depression has been associated with accelerated aging and cellular senescence. Indeed, several studies demonstrated an increase in senescence-associated secretory phenotype (SASP) proteins in individuals with late-life depression. However, it is unclear how the increased expression of SASP proteins relates to clinical presentation, including mental and physical health.
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