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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Cell phenotypes as activity biomarkers in patients with Systemic Lupus Erythematosus

2023; UNIVERSIDADE DE SÃO PAULO; Volume: 59; Linguagem: Inglês

10.1590/s2175-97902023e20052

ISSN

2175-9790

Autores

Cristina de Mello Gomide Loures, Tânia Mara Pinto Dabés Guimarães, Karine Silveste Ferreira, Marcos Vinícius Ferreira Silva, Luan Carlos Vieira Alves, Walter Batista Cicarini, Fernanda Freire Campos Nunes, Renato Vargas Consoli, Cláudia Lopes Santoro Neiva, Paulo Madureira de Pádua, Luara Isabela dos Santos, Jôsimar Dornelas Moreira, Vicente de Paulo Coelho Peixoto de Toledo, María das Graças Carvalho Ferriani,

Tópico(s)

Immune Cell Function and Interaction

Resumo

The pathogenesis of systemic lupus erythematosus (SLE) is complex. Few studies in Brazilian population have addressed cell phenotypes associated with immunological responses and their associations with SLE activity. The aim of this study is to investigate cell phenotypes associated to SLE diagnosis, treatment and activity. Twenty-eight SLE female patients (17 inactive, 11 active) and 10 healthy women were included in this study. Markers of natural killer (Nk), T and B cells in peripheral blood were evaluated by flow cytometry. Nkt cells were decreased only in SLE active patients. Activated CD4+, regulatory T FoxP3+ and B cells were decreased in both active and inactive SLE patients, compared to control group. The data corroborate the disruption of immune regulatory response in SLE patients and suggest phenotipic changes as possible biomarkers of SLE activity.

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