A Mass Spectrometric Labeling Strategy for High-Throughput Reaction Evaluation and Optimization: Exploring C−H Activation
2001; Wiley; Volume: 40; Issue: 1 Linguagem: Inglês
10.1002/1521-3773(20010105)40
ISSN1521-3773
AutoresJason W. Szewczyk, Rebecca L. Zuckerman, Robert G. Bergman, Jonathan A. Ellman,
Tópico(s)Chemical Synthesis and Analysis
ResumoThe functional groups and heterocyclic classes known to be compatible with a directed C−H activation with [Ru3(CO)12] has been expanded through development of a new substrate screening strategy. Following C−H activation, a library of products is MS-labeled and rapidly evaluated by positive ion electrospray ionization mass spectrometry (see scheme) to directly identify successful products and their yields.
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