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Adjuvant conditioning induces an immunosuppressive milieu that delays alloislet rejection through the expansion of myeloid-derived suppressor cells

2023; Elsevier BV; Volume: 23; Issue: 7 Linguagem: Inglês

10.1016/j.ajt.2023.04.015

1600-6143

Jifu Ge, Weikang Pan, Noel Feeney, Leah Ott, Emily Anderson, Alessandro Alessandrini, Ivan Zanoni, James F. Markmann, Alex G. Cuenca,

Reproductive System and Pregnancy

Advances in immunosuppression have been relatively stagnant over the past 2 decades, and transplant recipients continue to experience long-term morbidity associated with immunosuppression regimens. Strategies to reduce or eliminate the dosage of immunosuppression medications are needed. We discovered a novel administration strategy using the classic adjuvant alum to condition murine islet transplant recipients, known as adjuvant conditioning (AC), to expand both polymorphonuclear and monocytic myeloid-derived suppressive cells (MDSCs) in vivo. These AC MDSCs potently suppress T cell proliferation when cultured together in vitro. AC MDSCs also facilitate naïve CD4