The flipside of DNA Flipons and alternative nucleic acid structures
2023; Issue: 135 Linguagem: Inglês
10.32907/ro-135-4320813463
ISSN2517-7028
Tópico(s)RNA and protein synthesis mechanisms
ResumoOur DNA holds a wealth of information coding for an almost endless number of end-product possibilities.Seventy years on from the discovery of DNA, we're still learning about the intricacies of our genome -and have much more to learn.An area of focus for Dr Alan Herbert, InsideOutBio Inc, USA, is alternative nucleic acid structures.These differ in structure from the original B-DNA first described by Watson and Crick in 1953.However, the genome contains many repeat sequences capable of forming alternative DNA structures under physiological conditions, like left-handed Z-DNA and four-stranded quadruplexes.These genetically encoded elements are called flipons.
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