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Persistent SARS-CoV-2 infection with multiple clinical relapses in two patients with follicular lymphoma treated with bendamustine and obinutuzumab or rituximab

2023; Springer Science+Business Media; Volume: 51; Issue: 5 Linguagem: Inglês

10.1007/s15010-023-02039-2

1439-0973

Erica Franceschini, Mariachiara Pellegrino, Vera Todisco, Giovanni Dolci, Francesca Bettelli, Marianna Meschiari, Andrea Bedini, Giulia Fregni‐Serpini, Antonella Grottola, Giovanni Guaraldi, Monica Pecorari, Mario Sarti, Mario Luppi, Carlo Federico Perno, Cristina Mussini,

SARS-CoV-2 and COVID-19 Research

People with hematologic malignancies have a significantly higher risk of developing severe and protracted forms of SARS-CoV-2 infection compared to immunocompetent patients, regardless of vaccination status.We describe two cases of prolonged SARS-CoV-2 infection with multiple relapses of COVID-19 pneumonia in patients with follicular lymphoma treated with bendamustine and obinutuzumab or rituximab. The aim is to highlight the complexity of SARS-CoV-2 infection in this fragile group of patients and the necessity of evidence-based strategies to treat them properly.Patients with hematological malignancies treated with bendamustine and anti-CD20 antibodies had a significant risk of prolonged and relapsing course of COVID-19. Specific preventive and therapeutic strategies should be developed for this group of patients.