Interleukin-1 Blockade in Cardiac Sarcoidosis: A Pilot Study
2023; Lippincott Williams & Wilkins; Volume: 16; Issue: 5 Linguagem: Inglês
10.1161/circep.123.011869
ISSN1941-3149
AutoresJordana Kron, Thomas Crawford, Frank Bogun, Jennifer H. Jordan, Todd M. Koelling, Huzaefah Syed, Aamer Syed, Thomas Iden, Kelly Polly, Emily Federmann, Kirsta Bray, Sangeeta Lathkar‐Pradhan, Amy C. Ladd, Virginia M. Dickson, Andrew Barron, Anahita Tavoosi, Rob Beanlands, David H. Birnie, Kenneth A. Ellenbogen, Benjamín Van Tassell, W. Gregory Hundley, Antonio Abbate,
Tópico(s)Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
ResumoHomeCirculation: Arrhythmia and ElectrophysiologyVol. 16, No. 5Interleukin-1 Blockade in Cardiac Sarcoidosis: A Pilot Study No AccessLetterRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessLetterRequest AccessFull TextInterleukin-1 Blockade in Cardiac Sarcoidosis: A Pilot Study Jordana Kron, Thomas Crawford, Frank Bogun, Jennifer H. Jordan, Todd Koelling, Huzaefah Syed, Aamer Syed, Thomas Iden, Kelly Polly, Emily G. Federmann, Kirsta Bray, Sangeeta Lathkar-Pradhan, Amy Ladd, Virginia M. Dickson, Andrew Barron, Anahita Tavoosi, Rob Beanlands, David Birnie, Kenneth Ellenbogen, Benjamin W. Van Tassell, W. Gregory Hundley and Antonio Abbate Jordana KronJordana Kron Correspondence to: Jordana Kron, MD, Virginia Commonwealth University Medical Center, PO Box 980053, Richmond, VA 23298. Email E-mail Address: [email protected] https://orcid.org/0000-0002-3397-0535 Virginia Commonwealth University (VCU) Pauley Heart Center (J.K., J.H.J., A.L., V.M.D., A.B., K.E., B.W.V.T., W.G.H.), Virginia Commonwealth University, Richmond. Search for more papers by this author , Thomas CrawfordThomas Crawford Cardiovascular Center, University of Michigan, Ann Arbor (T.C., F.B., T.K., K.B., S.L.-P.). Search for more papers by this author , Frank BogunFrank Bogun Cardiovascular Center, University of Michigan, Ann Arbor (T.C., F.B., T.K., K.B., S.L.-P.). Search for more papers by this author , Jennifer H. JordanJennifer H. Jordan https://orcid.org/0000-0003-1001-1849 Virginia Commonwealth University (VCU) Pauley Heart Center (J.K., J.H.J., A.L., V.M.D., A.B., K.E., B.W.V.T., W.G.H.), Virginia Commonwealth University, Richmond. Department of Biomedical Engineering (J.H.J.), Virginia Commonwealth University, Richmond. Search for more papers by this author , Todd KoellingTodd Koelling Cardiovascular Center, University of Michigan, Ann Arbor (T.C., F.B., T.K., K.B., S.L.-P.). Search for more papers by this author , Huzaefah SyedHuzaefah Syed Division of Rheumatology, Allergy, and Immunology (H.S.), Virginia Commonwealth University, Richmond. Search for more papers by this author , Aamer SyedAamer Syed Division of Pulmonary and Critical Care (A.S., T.I., K.P., E.G.F.), Virginia Commonwealth University, Richmond. Search for more papers by this author , Thomas IdenThomas Iden Division of Pulmonary and Critical Care (A.S., T.I., K.P., E.G.F.), Virginia Commonwealth University, Richmond. Search for more papers by this author , Kelly PollyKelly Polly Division of Pulmonary and Critical Care (A.S., T.I., K.P., E.G.F.), Virginia Commonwealth University, Richmond. Search for more papers by this author , Emily G. FedermannEmily G. Federmann Division of Pulmonary and Critical Care (A.S., T.I., K.P., E.G.F.), Virginia Commonwealth University, Richmond. Search for more papers by this author , Kirsta BrayKirsta Bray Cardiovascular Center, University of Michigan, Ann Arbor (T.C., F.B., T.K., K.B., S.L.-P.). Search for more papers by this author , Sangeeta Lathkar-PradhanSangeeta Lathkar-Pradhan Cardiovascular Center, University of Michigan, Ann Arbor (T.C., F.B., T.K., K.B., S.L.-P.). Search for more papers by this author , Amy LaddAmy Ladd Virginia Commonwealth University (VCU) Pauley Heart Center (J.K., J.H.J., A.L., V.M.D., A.B., K.E., B.W.V.T., W.G.H.), Virginia Commonwealth University, Richmond. Search for more papers by this author , Virginia M. DicksonVirginia M. Dickson Virginia Commonwealth University (VCU) Pauley Heart Center (J.K., J.H.J., A.L., V.M.D., A.B., K.E., B.W.V.T., W.G.H.), Virginia Commonwealth University, Richmond. Search for more papers by this author , Andrew BarronAndrew Barron https://orcid.org/0000-0002-0214-8186 Virginia Commonwealth University (VCU) Pauley Heart Center (J.K., J.H.J., A.L., V.M.D., A.B., K.E., B.W.V.T., W.G.H.), Virginia Commonwealth University, Richmond. Search for more papers by this author , Anahita TavoosiAnahita Tavoosi Department of Medicine (Cardiology), University of Ottawa Heart Institute, Canada (A.T., R.B., D.B.). Search for more papers by this author , Rob BeanlandsRob Beanlands https://orcid.org/0000-0001-7857-8169 Department of Medicine (Cardiology), University of Ottawa Heart Institute, Canada (A.T., R.B., D.B.). Search for more papers by this author , David BirnieDavid Birnie https://orcid.org/0000-0001-6495-1428 Department of Medicine (Cardiology), University of Ottawa Heart Institute, Canada (A.T., R.B., D.B.). Search for more papers by this author , Kenneth EllenbogenKenneth Ellenbogen https://orcid.org/0000-0002-8527-569X Virginia Commonwealth University (VCU) Pauley Heart Center (J.K., J.H.J., A.L., V.M.D., A.B., K.E., B.W.V.T., W.G.H.), Virginia Commonwealth University, Richmond. Search for more papers by this author , Benjamin W. Van TassellBenjamin W. Van Tassell https://orcid.org/0000-0003-0688-4487 Virginia Commonwealth University (VCU) Pauley Heart Center (J.K., J.H.J., A.L., V.M.D., A.B., K.E., B.W.V.T., W.G.H.), Virginia Commonwealth University, Richmond. Department of Pharmacotherapy and Outcomes Science (B.W.V.T.), Virginia Commonwealth University, Richmond. Search for more papers by this author , W. Gregory HundleyW. Gregory Hundley https://orcid.org/0000-0002-2433-8853 Virginia Commonwealth University (VCU) Pauley Heart Center (J.K., J.H.J., A.L., V.M.D., A.B., K.E., B.W.V.T., W.G.H.), Virginia Commonwealth University, Richmond. Search for more papers by this author and Antonio AbbateAntonio Abbate https://orcid.org/0000-0002-1930-785X Robert M. Berne Cardiovascular Research Center, Charlottesville, VA (A.A.). Division of Cardiology, Heart and Vascular Center, University of Virginia, Charlottesville (A.A.). Search for more papers by this author Originally published24 Apr 2023https://doi.org/10.1161/CIRCEP.123.011869Circulation: Arrhythmia and Electrophysiology. 2023;16FootnotesFor Sources of Funding and Disclosures, see page 311.Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04017936.Correspondence to: Jordana Kron, MD, Virginia Commonwealth University Medical Center, PO Box 980053, Richmond, VA 23298. Email jordana.kron@vcuhealth.orgReferences1. Kron J, Crawford T. The cardiac sarcoidosis consortium: elucidating a mysterious disease through collaborative research.Eur Heart J. 2022; 43:3991. doi: 10.1093/eurheartj/ehac358CrossrefMedlineGoogle Scholar2. Birnie DH, Sauer WH, Bogun F, Cooper JM, Culver DA, Duvernoy CS, Judson MA, Kron J, Mehta D, Cosedis Nielsen J, et al. HRS expert consensus statement on the diagnosis and management of arrhythmias associated with cardiac sarcoidosis.Heart Rhythm. 2014; 11:1305–1323. doi: 10.1016/j.hrthm.2014.03.043CrossrefMedlineGoogle Scholar3. Kron J, Mauro AG, Bonaventura A, Toldo S, Salloum FN, Ellenbogen KA, Abbate A. Inflammasome formation in granulomas in cardiac sarcoidosis.Circ Arrhythm Electrophysiol. 2019; 12:e007582. doi: 10.1161/CIRCEP.119.007582LinkGoogle Scholar4. Kron J, Crawford T, Mihalick V, Bogun F, Jordan JH, Koelling T, Syed H, Syed A, Iden T, Polly K, et al. Interleukin-1 blockade in cardiac sarcoidosis: study design of the multimodality assessment of granulomas in cardiac sarcoidosis: Anakinra Randomized Trial (MAGiC-ART).J Transl Med. 2021; 19:460. doi: 10.1186/s12967-021-03130-8CrossrefMedlineGoogle Scholar5. Abbate A, Toldo S, Marchetti C, Kron J, Van Tassell BW, Dinarello CA. Interleukin-1 and the inflammasome as therapeutic targets in cardiovascular disease.Circ Res. 2020; 126:1260–1280. doi: 10.1161/CIRCRESAHA.120.315937LinkGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetails May 2023Vol 16, Issue 5 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCEP.123.011869PMID: 37092332 Originally publishedApril 24, 2023 KeywordsbiomarkersinflammasomesinterleukinspericarditissarcoidosisPDF download Advertisement SubjectsBiomarkersInflammationInflammatory Heart DiseaseNuclear Cardiology and PET
Referência(s)