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Subacute THYROiditis Related to SARS-CoV-2 VAccine and Covid-19 (THYROVAC Study): A Multicenter Nationwide Study

2023; Oxford University Press; Volume: 108; Issue: 10 Linguagem: Inglês

10.1210/clinem/dgad235

1945-7197

Adnan Batman, Dilek Yazıcı, Oğuz Dikbaş, Kemal Ağbaht, Emre Sedar Saygılı, İbrahim Demirci, Nurbanu Bursa, Görkem Ayas, Cüneyd Anıl, Mustafa Cesur, Fatma Nur Korkmaz, Adile Begüm Bahçecioğlu, Demet Çorapçıoğlu, Murat Faik Erdoğan, Hayri Bostan, Murat Çalapkulu, Sema Hepşen, Bekir Uçan, Erman Çakal, Bağdagül Yüksel Güler, Cem Haymana, Süleyman Hilmi İpekçi, Selami Aydın, Havva Sezer, Seçil Özışık, Oğuzhan Deyneli, Faruk Alagöl, Refik Tanakol, Mustafa Eroğlu, Ümmü Mutlu, Hülya Hacışahinoğulları, Ayşe Kubat Üzüm, Canan Demir, Gönül Koç, Sevde Nur Fırat, Tülay Omma, Nurcan İnce, Şefika Burçak Polat, Oya Topaloğlu, Cevdet Aydın, Bekir Çakır, Çiğdem Tura Bahadır, Mehmet Güven, Mehmet Sözen, Alev Selek, Zeynep Cantürk, Berrin Çetinarslan, Mustafa Aydemir, Işılay Taşkaldıran, Yusuf Bozkuş, Özlem Turhan İyidir, Filiz Ekşi Haydardedeoğlu, Seda Erem Basmaz, Mehmet Çağrı Ünal, Tevfik Demir, Ayten Oğuz, Özlem Çelik, Merve Yılmaz, Aykut Çimşir, Serdar Kayıhan, Ziynet Alphan Üç, Sakin Tekin, Ömercan Topaloğlu, Başak Özgen Saydam, Yasemin AYDOĞAN ÜNSAL, Özge Özer, Göknur Yorulmaz, Kader Uğur, Sezin Doğan Çakır, Mehmet Aşık, Mustafa Ünübol, Selin Genç, Burak Andaç, Mine Okur, Özlem Doğan, Ersen Karakılıç, Gökçen Ünal Kocabaş, Cem Onur Kıraç, Güven Barış Cansu, Meliha Melin Uygur, Zafer Pekkolay, Sadettin S. Ozturk, Aşkın Güngüneş, Eren Gürkan, Lezan Keskin, Kenan Çağlayan, Yasemin Günay, Eren İmre, Selçuk Yusuf Şener, Ahmet Toygar Kalkan, Deniz Engin Gök, Mustafa Şahi̇n,

Vitamin D Research Studies

Abstract Context The aims of the study are to compare characteristics of subacute thyroiditis (SAT) related to different etiologies, and to identify predictors of recurrence of SAT and incident hypothyroidism. Methods This nationwide, multicenter, retrospective cohort study included 53 endocrinology centers in Turkey. The study participants were divided into either COVID-19–related SAT (Cov-SAT), SARS-CoV-2 vaccine–related SAT (Vac-SAT), or control SAT (Cont-SAT) groups. Results Of the 811 patients, 258 (31.8%) were included in the Vac-SAT group, 98 (12.1%) in the Cov-SAT group, and 455 (56.1%) in the Cont-SAT group. No difference was found between the groups with regard to laboratory and imaging findings. SAT etiology was not an independent predictor of recurrence or hypothyroidism. In the entire cohort, steroid therapy requirement and younger age were statistically significant predictors for SAT recurrence. C-reactive protein measured during SAT onset, female sex, absence of antithyroid peroxidase (TPO) positivity, and absence of steroid therapy were statistically significant predictors of incident (early) hypothyroidism, irrespective of SAT etiology. On the other hand, probable predictors of established hypothyroidism differed from that of incident hypothyroidism. Conclusion Since there is no difference in terms of follow-up parameters and outcomes, COVID-19– and SARS-CoV-2 vaccine–related SAT can be treated and followed up like classic SATs. Recurrence was determined by younger age and steroid therapy requirement. Steroid therapy independently predicts incident hypothyroidism that may sometimes be transient in overall SAT and is also associated with a lower risk of established hypothyroidism.