Produção Nacional
Revisado por pares
Potential Biomarkers of impulsivity in mild traumatic brain injury: A pilot study
2023; Elsevier BV; Volume: 449; Linguagem: Inglês
10.1016/j.bbr.2023.114457
ISSN1872-7549
AutoresMaíra Glória de Freitas Cardoso, João Luís Vieira Monteiro de Barros, Rafael Alves Bonfim de Queiroz, Natália Pessoa Rocha, Carlisa Silver, Agnes Stéphanie da Silva, Ewelin Wasner Machado da Silva, Isadora Gonçalves Roque, Júlia de Lima Carvalho, Laura Ferreira dos Santos, Letícia Bitencourt Cota, Lucas Miranda Lemos, Mariana Figueiredo Miranda, Millena Figueiredo Miranda, Pedro Parenti Vianna, Rafael Arantes Oliveira, Tiago de Oliveira Furlam, Túlio Safar Sarquis Soares, Vinícius Sousa Pietra Pedroso, Rodrigo Moreira Faleiro, Érica Leandro Marciano Vieira, Antônio Lúcio Teixeira, Leonardo Cruz de Souza, Aline Silva de Miranda,
Tópico(s)Cardiac Arrest and Resuscitation
ResumoVery few studies have investigated cognition and impulsivity following mild traumatic brain injury (mTBI) in the general population. Furthermore, the neurobiological mechanisms underlying post-TBI neurobehavioral syndromes are complex and remain to be fully clarified. Herein, we took advantage of machine learning based-modeling to investigate potential biomarkers of mTBI-associated impulsivity. Twenty-one mTBI patients were assessed within one-month post-TBI and their data were compared to 19 healthy controls on measures of impulsivity (Barratt Impulsiveness Scale – BIS), executive functioning, episodic memory, self-report cognitive failures and blood biomarkers of inflammation, vascular and neuronal damage. mTBI patients were significantly more impulsive than controls in BIS total and subscales. Serum levels of sCD40L, Cathepsin D, IL-4, Neuropilin-1, IFN-α2, and Copeptin were associated with impulsivity in mTBI patients. Besides showing that mTBI are associated with impulsivity in non-military people, we unveiled different pathophysiological pathways potentially implicated in mTBI-related impulsivity.
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