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Genetic and clinical determinants of telomere length

2023; Elsevier BV; Volume: 4; Issue: 3 Linguagem: Inglês

10.1016/j.xhgg.2023.100201

2666-2477

Patrick D. Allaire, Jing He, John E. Mayer, Luke Moat, Peter Gerstenberger, Reynor Wilhorn, Sierra Strutz, David S.L. Kim, Chenjie Zeng, Nancy J. Cox, Jerry W. Shay, Joshua C. Denny, Lisa Bastarache, Scott J. Hebbring,

Epigenetics and DNA Methylation

Many epidemiologic studies have identified important relationships between leukocyte telomere length (LTL) with genetics and health. Most of these studies have been significantly limited in scope by focusing predominantly on individual diseases or restricted to GWAS analysis. Using two large patient populations derived from Vanderbilt University and Marshfield Clinic biobanks linked to genomic and phenomic data from medical records, we investigated the inter-relationship between LTL, genomics, and human health. Our GWAS confirmed 11 genetic loci previously associated with LTL and two novel loci in