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Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity

2023; American Association for the Advancement of Science; Volume: 9; Issue: 17 Linguagem: Inglês

10.1126/sciadv.add4984

2375-2548

Amand F. Schmidt, Mimount Bourfiss, Abdulrahman Alasiri, Esther Puyol‐Antón, Sandesh Chopade, Marion van Vugt, Sander W. van der Laan, Christian Groß, Chris Clarkson, Albert Henry, Tom Lumbers, Pim van der Harst, Nora Franceschini, Joshua C. Bis, Birgitta K. Velthuis, Anneline S.J.M. te Riele, Aroon D. Hingorani, Bram Ruijsink, Folkert W. Asselbergs, Jessica van Setten, Chris Finan,

Cardiomyopathy and Myosin Studies

Dysfunction of either the right or left ventricle can lead to heart failure (HF) and subsequent morbidity and mortality. We performed a genome-wide association study (GWAS) of 16 cardiac magnetic resonance (CMR) imaging measurements of biventricular function and structure.