THE EPIDEMIOLOGY AND PATHOPHYSIOLOGY OF ERECTILE DYSFUNCTION
1999; Lippincott Williams & Wilkins; Volume: 161; Issue: 1 Linguagem: Inglês
10.1016/s0022-5347(01)62045-7
ISSN1527-3792
Autores Tópico(s)Urinary Bladder and Prostate Research
ResumoNo AccessJournal of UrologyClinical Urology: Review Article1 Jan 1999THE EPIDEMIOLOGY AND PATHOPHYSIOLOGY OF ERECTILE DYSFUNCTION ARNOLD MELMAN and J. CLIVE GINGELL ARNOLD MELMANARNOLD MELMAN and J. CLIVE GINGELLJ. CLIVE GINGELL View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)62045-7AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Published studies on the epidemiology of erectile dysfunction and the physiology/pathophysiology of erectile function are reviewed. Materials and Methods: A literature search of more than 400 studies of the epidemiology and pathophysiology of impotence and erectile dysfunction published during the last 3 decades was conducted and the most pertinent articles are discussed. Results: It has been estimated that the prevalence of erectile dysfunction of all degrees is 52% in men 40 to 70 years old, with higher rates in those older than 70 years. Erectile dysfunction has a significant negative impact on quality of life. Risk factors for erectile dysfunction include aging, chronic illnesses, various medications and cigarette smoking. A nitric oxide/cyclic guanosine monophosphate mechanism has an important role in mediating the corporal smooth muscle relaxation necessary for erectile function. Other mechanisms involving neuropeptides, gap junctions and ion channels also may modulate corporal smooth muscle tone. Erectile dysfunction can be due to vasculogenic, neurogenic, hormonal and/or psychogenic factors as well as alterations in the nitric oxide/cyclic guanosine monophosphate pathway or other regulatory mechanisms, resulting in an imbalance in corporal smooth muscle contraction and relaxation. Conclusions: Erectile dysfunction is a common condition associated with aging, chronic illnesses and various modifiable risk factors. Normal penile erection is a hemodynamic process that is dependent on corporal smooth muscle relaxation mediated by parasympathetic neurotransmission, nitric oxide, and possibly other regulatory factors and electrophysiological events. As more knowledge is gained of the physiology and regulatory factors that mediate normal erectile function, the mechanisms involved in the pathophysiology of erectile dysfunction should be further elucidated. References 1 : NIH Consensus Conference. Impotence. J.A.M.A.1993; 270: 83. Google Scholar 2 : Advances in the assessment of organic causes of impotence. Brit. J. Hosp. Med.1986; 36: 186. Google Scholar 3 : Male erectile dysfunction assessment and treatment options. Compr. Ther.1994; 20: 669. Google Scholar 4 : Experimental approaches to the development of pharmacological therapies for erectile dysfunction. In: Sexual Pharmacology. Edited by . Oxford: Oxford Medical Publications1993: 87. Google Scholar 5 : Sexual Behavior in the Human Male. 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Google Scholar Department of Urology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York, and the Department of Urology, Southmead Hospital, Bristol, United Kingdom© 1999 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byKirshenbaum E, Nelson M, Hehemann M, Kothari A, Eguia E, Farooq A, Bresler L, Gupta G and Santos G (2018) Impact of Post-Hospital Syndrome on Penile Prosthesis Outcomes: A Period of Global Health RiskJournal of Urology, VOL. 201, NO. 1, (154-159), Online publication date: 1-Jan-2019.Gleason J, Slezak J, Jung H, Reynolds K, Van Den Eeden S, Haque R, Quinn V, Loo R and Jacobsen S (2018) Regular Nonsteroidal Anti-Inflammatory Drug Use and Erectile DysfunctionJournal of Urology, VOL. 185, NO. 4, (1388-1393), Online publication date: 1-Apr-2011.Pavone C, Curto F, Anello G, Serretta V, Almasio P and Pavone-Macaluso M (2018) Prospective, Randomized, Crossover Comparison of Sublingual Apomorphine (3 mg) With Oral Sildenafil (50 mg) for Male Erectile DysfunctionJournal of Urology, VOL. 179, NO. 5S, (S92-S94), Online publication date: 1-May-2008.Heidler S, Temml C, Broessner C, Mock K, Rauchenwald M, Madersbacher S and Ponholzer A (2018) Is the Metabolic Syndrome an Independent Risk Factor for Erectile Dysfunction?Journal of Urology, VOL. 177, NO. 2, (651-654), Online publication date: 1-Feb-2007.BENNETT N, KIM J, WOLFE D, SASAKI K, YOSHIMURA N, GOINS W, HUANG S, NELSON J, de GROAT W, GLORIOSO J and CHANCELLOR M (2018) IMPROVEMENT IN ERECTILE DYSFUNCTION AFTER NEUROTROPHIC FACTOR GENE THERAPY IN DIABETIC RATSJournal of Urology, VOL. 173, NO. 5, (1820-1824), Online publication date: 1-May-2005.SUN P and SWINDLE R (2018) ARE MEN WITH ERECTILE DYSFUNCTION MORE LIKELY TO HAVE HYPERTENSION THAN MEN WITHOUT ERECTILE DYSFUNCTION? 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Volume 161Issue 1January 1999Page: 5-11 Advertisement Copyright & Permissions© 1999 by American Urological Association, Inc.MetricsAuthor Information ARNOLD MELMAN More articles by this author J. CLIVE GINGELL More articles by this author Expand All Advertisement PDF downloadLoading ...
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