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Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study

2023; Springer Science+Business Media; Volume: 261; Issue: 10 Linguagem: Inglês

10.1007/s00417-023-06072-7

1435-702X

Mariza Fevereiro‐Martins, Ana Carolina Santos, Carlos Marques‐Neves, Hercília Guimarães, Manuel Bicho, C. Afonso, Joana Ferreira, Rita Espí­rito Santo, Filipa Teixeira, Rita De Rosa, Cristina Vaz Carneiro, Marta Ferreira, Teresa Hernández‐Sampelayo, Luísa Neiva, Sandra Pereira, Sofia Aires, Pedro Parreira, Zuzana Melnik, Jo�ão Ricardo Faria, Joana Teixeira, Pedro Barros, Juliana M. P. Almeida, Bruna Malheiro, Patrícia Cunha Rodrigues, Luís Albuquerque, Alice Freitas, Pedro Barros, Nadezda Kotchekova, Rui A. de Freitas, Ana Cristina Tavares Silveira, Ana Ferreira, Benvinda Morais, Susana Teixeira, Mafalda Mota, Maria Guerra, Lúcia Coimbra, João Gigante, Muriel Ferreira, Patrícia Lapa, Madalena Monteiro, Mário Alfaiate, Teresa Rodrigues, Teresa Casas, Marta Rosário, Renato Silva, Jorge Breda, Filipa Bazenga, João António Pinto,

Neonatal Health and Biochemistry

Abstract Purpose To evaluate complete blood count (CBC) parameters in the first week of life as predictive biomarkers for the development of retinopathy of prematurity (ROP). Methods Multicenter, prospective, observational study of a cohort of preterm infants born with gestational age (GA) < 32 weeks or birth weight < 1500 g in eight Portuguese neonatal intensive care units. All demographic, clinical, and laboratory data from the first week of life were collected. Univariate logistic regression was used to assess risk factors for ROP and then multivariate regression was performed. Results A total of 455 infants were included in the study. The median GA was 29.6 weeks, and the median birth weight was 1295 g. One hundred and seventy-two infants (37.8%) developed ROP. Median values of erythrocytes ( p < 0.001), hemoglobin ( p < 0.001), hematocrit ( p < 0.001), mean corpuscular hemoglobin concentration ( p < 0.001), lymphocytes ( p = 0.035), and platelets ( p = 0.003) of the group of infants diagnosed with ROP any stage were lower than those without ROP. Mean corpuscular volume (MCV) ( p = 0.044), red blood cell distribution width (RDW) ( p < 0.001), erythroblasts ( p < 0.001), neutrophils ( p = 0.030), neutrophils-lymphocytes ratio ( p = 0.028), and basophils ( p = 0.003) were higher in the ROP group. Higher values of MCV, erythroblasts, and basophils remained significantly associated with ROP after multivariate regression. Conclusion In our cohort, the increase in erythroblasts, MCV, and basophils in the first week of life was significantly and independently associated with the development of ROP. These CBC parameters may be early predictive biomarkers for ROP.