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A chemically inducible IL-2 receptor signaling complex allows for effective in vitro and in vivo selection of engineered CD4+ T cells

2023; Elsevier BV; Volume: 31; Issue: 8 Linguagem: Inglês

10.1016/j.ymthe.2023.04.021

1525-0024

Peter J. Cook, Su Jung Yang, Gene I. Uenishi, Annaiz Grimm, Samuel E. West, Lijie Wang, Chester Jacobs, Andrea Repele, Travis Drow, Ahmad Boukhris, Noelle Dahl, Karen Sommer, Andrew M. Scharenberg, David J. Rawlings,

T-cell and B-cell Immunology

Engineered T cells represent an emerging therapeutic modality. However, complex engineering strategies can present a challenge for enriching and expanding therapeutic cells at clinical scale. In addition, lack of in vivo cytokine support can lead to poor engraftment of transferred T cells, including regulatory T cells (T