Produção Nacional
Revisado por pares
Metabolic Adaptations Correlated with Antibody Response after Immunization with Inactivated SARS-CoV-2 in Brazilian Subjects
2023; American Chemical Society; Volume: 22; Issue: 6 Linguagem: Inglês
10.1021/acs.jproteome.3c00014
ISSN1535-3907
AutoresJeane de Souza Nogueira, Cíntia Barros Santos-Rebouças, Rafael Mina Piergiorge, Ana Paula Valente, Marcos C. Gama-Almeida, Tatiana El‐Bacha, Maria Luiza Lopes Moreira, Bruna Silva Baptista Marques, Jessica Rodrigues de Siqueira, Erika Martins de Carvalho, Orlando da Costa Ferreira, Luís Cristóvão Pôrto, Tatiana Kelly da Silva Fidalgo, Gilson Costa dos Santos,
Tópico(s)Diabetes and associated disorders
ResumoThe adsorbed vaccine SARS-CoV-2 (inactivated) produced by Sinovac (SV) was the first vaccine against COVID-19 to be used in Brazil. To understand the metabolic effects of SV in Brazilian subjects, NMR-based metabolomics was used, and the immune response was studied in Brazilian subjects. Forty adults without (group–, n = 23) and with previous COVID-19 infection (group+, n = 17) were followed-up for 90 days postcompletion of the vaccine regimen. After 90 days, our results showed that subjects had increased levels of lipoproteins, lipids, and N-acetylation of glycoproteins (NAG) as well as decreased levels of amino acids, lactate, citrate, and 3-hydroxypropionate. NAG and threonine were the highest correlated metabolites with N and S proteins, and neutralizing Ab levels. This study sheds light on the immunometabolism associated with the use of SV in Brazilian subjects from Rio de Janeiro and identifies potential metabolic markers associated with the immune status.
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