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Drug-Resistant Epilepsy

2011; Massachusetts Medical Society; Volume: 365; Issue: 10 Linguagem: Inglês

10.1056/nejmra1004418

1533-4406

Patrick Kwan, Steven C. Schachter, Martin J. Brodie,

Pharmacological Effects and Toxicity Studies

Nearly a quarter of patients with seizures have drug-resistant epilepsy. This review examines how this diagnosis should be established and how to recognize pseudoresistance. It explains possible mechanisms of drug-resistant epilepsy and presents treatment strategies.